Description
Kobe 0065 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. In vitro, this compound inhibits cell growth and induces apoptosis and in vivo, it decreases tumor growth.
Product Unit Size | Cost | Quantity | Stock |
---|
Kobe 0065 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. In vitro, this compound inhibits cell growth and induces apoptosis and in vivo, it decreases tumor growth.
Cas No. | 436133-68-5 |
---|---|
Purity | ≥99% |
Formula | C15H11ClF3N5O4S |
Formula Wt. | 449.79 |
IUPAC Name | N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide |
Solubility | ethanol 10mM with gentle warming water 5 mM with gentle warming |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.
Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.
BRD2/4/9 and CECR2 inhibitor.
Staurosporine analog; PKC inhibitor.
β2-adrenergic agonist, BChE inhibitor.
ACE inhibitor.
mTOR inhibitor.
STING antagonist
β2-adrenergic agonist.
VEGFR2, PDGFR, FGFR2 inhibitor.
Effective against gram-positive pathogens
Nucleoside (thymidine) analog; DNA chain termin...
PARP1/2 inhibitor.
Endogenous peptide hormone; guanyl cyclase C ag...
pan-Raf inhibitor.
Cannabinoid receptor 2 selective agonist.
Tricyclic antidepressant; potential D1/2 antago...
Inhibitor of PI3K.
AChE and BChE inhibitor.
SRPK1 inhibitor.
Polyphenolic compound present in black tea.
Nucleoside (deoxyadenosine) analog; DNA chain t...