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Laminin Peptide SIKVAV

Laminin Peptide SIKVAV

Product ID L0250
Cas No.
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $110.50 In stock
5 mg $393.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

This hexapeptide is equivalent to a sequence found on the A1 chain of laminin; it exhibits pro-angiogenic activity. Like other laminin peptides, this sequence can be used in combination with chemotherapeutics to deliver the drug to target tumor tissues. In vitro, this peptide increases vessel formation and migration. This peptide also increases secretion of matrix metalloproteinases 2 and 9 (MMP2/9), modulating the morphology of salivary gland adenoid cystic carcinoma cells.

Product Info

Purity

≥98%

Formula

C82H149N31O26S

Formula Wt.

2017.35

Synonym

Laminin A Chain (2091-2108)

Solubility

Soluble in water.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L0250 MSDS PDF

Info Sheet

L0250 Info Sheet PDF

References

Stevenson M, Hale AB, Hale SJ, et al. Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via alpha6-integrins. Cancer Gene Ther. 2007 Apr;14(4):335-45. PMID: 17235355.

Freitas VM, Scheremeta B, Hoffman MP, et al. Laminin-1 and SIKVAV a laminin-1-derived peptide, regulate the morphology and protease activity of a human salivary gland adenoid cystic carcinoma cell line. Oral Oncol. 2004 May;40(5):483-9. PMID: 15006619.

Kibbey MC, Corcoran ML, Wahl LM, et al. Laminin SIKVAV peptide-induced angiogenesis in vivo is potentiated by neutrophils. J Cell Physiol. 1994 Jul;160(1):185-93. PMID: 7517404.

Custom Order

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