Lansoprazole

Name: Lansoprazole
SKU: L0254
Availability: InStock

Product ID L0254

Cas No. 103577-45-3

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Lansoprazole is a proton pump (H+/K+ ATPase) inhibitor (PPI) that exhibits antacid and anti-inflammatory activities. Lansoprazole is clinically used to treat gastroesophageal reflux disease (GERD). Lansoprazole inhibits indomethacin-induced gastric damage by preventing activation of mitochondria- and Fas-mediated apoptosis signaling pathways. Lansoprazole also inhibits PMA-induced activation of ERK1/2 and LPS-induced activation of p38 MAPK in neutrophils and decreases levels of pro-inflammatory cytokines in macrophages.

Product Info

Cas No.	103577-45-3
Purity	≥98%
Formula	C₁₆H₁₄F₃N₃O₂S
Formula Wt.	369.36
Chemical Name	1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2- pyridinyl)methyl)sulfinyl)-
IUPAC Name	2-[[3-methyl-4-(2,2, 2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
Synonym	AG-1749, Agopton, Lansox, Lanzor, Limpidex.
Melting Point	178-182°C (dec)
Solubility	Insoluble in water. Soluble in methanol and DMF.
Appearance	A white to off white powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	L0254 MSDS PDF
Info Sheet	L0254 Info Sheet PDF

References

Koshio O, Tansho S, Ubagai T, et al. Suppression of phosphorylation of extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase in polymorphonuclear leukocytes by the proton pump inhibitor lansoprazole. J Infect Chemother. 2010 Apr;16(2):100-6. PMID: 20094750.

Maity P, Bindu S, Choubey V, et al. Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal. J Biol Chem. 2008 May 23;283(21):14391-401. PMID: 18375387.

Hinoki A, Yoshimura K, Fujita K, et al. Suppression of proinflammatory cytokine production in macrophages by lansoprazole. Pediatr Surg Int. 2006 Nov;22(11):915-23. PMID: 16932910.

Shin JM, Cho YM, Sachs G. Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors. J Am Chem Soc. 2004 Jun 30;126(25):7800-11. PMID: 15212527.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

Lansoprazole

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

SU-9516

1-Isothiocyanato-8-(methylsulfonyl)-octane

Altretamine

Pituitary Adenylate Cyclase-activating Peptide (6-38), human/sheep/rat

Rasagiline Mesylate

Nivalenol

17α-Hydroxyprogesterone Caproate

Recombinant HIV-1 gp-41

Cinnarizine

Triclosan Methyl Ether

JZL184

Gemifloxacin Mesylate

Capsaicin, natural

R,S-(±)-Sulpiride

Pep-1 Peptide

[Des-Asp1]-Angiotensin I, human

Paliperidone

Iloprost

Enoxacin

Argipressin Acetate

Footer