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LEE011 is an inhibitor of CDK4/6 that exhibits anticancer chemotherapeutic activity. In neuroblastoma cells, LEE011 induces cell cycle arrest and cellular senescence, inhibiting proliferation. In animal models, LEE011 inhibits tumor xenograft growth.
| Cas No. | 1211441-98-3 |
|---|---|
| Purity | ≥98% |
| Formula | C23H30N8O |
| Formula Wt. | 434.54 |
| IUPAC Name | 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Synonym | LEE011, Ribociclib |
| Solubility | DMSO 7 mg/mL (16.1 mM) Water Insoluble Ethanol Insoluble |
| Appearance | Off-white Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Rader J, Russell MR, Hart LS, et al. Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82. PMID: 24045179.