• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Lercanidipine Hydrochloride

Lercanidipine Hydrochloride

Product ID L1869
Cas No. 132866-11-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $68.30 In stock
50 mg $131.30 In stock
250 mg $183.80 In stock
1 g $262.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lercanidipine is a dihydropyridine calcium channel blocker. It significantly countered wall thickening and luminal narrowing on small sized arteries. This compound and other similar dihydropyridine-type Ca2+ antagonists exert protective effect on retinal that include reduced thickness of retina and of inner plexiform, outer nuclear and layer of inner and outer segments plus outer limiting layer, and loss of ganglionic neurons. Lercanidipine consistently decreased MMP-9 activity and reduced oxidative stress in hypertensive patients. Lercanidipine treatment of spontaneously hypertensive rats (SHR) during 6 weeks was able to revert the deleterious effects of hypertension on cortical bone density and on the number of TRAP+ cells in the tibia of SHR.

Product Info

Cas No.

132866-11-6

Purity

≥98%

Formula

C36H41N3O6・HCl

Formula Wt.

648.20

Chemical Name

5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride

IUPAC Name

1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methyl-2-propanyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)

Synonym

Cardiovasc, Corifeo

Solubility

Soluble in DMSO (100 mM), ethanol (10 mM), water (partly), chloroform, and methanol.

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

L1869 MSDS PDF

Info Sheet

L1869 Info Sheet PDF

References

Sabbatini M1, Leonardi A, Testa R, et al. Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 2002 Jan;39(1):39-48. PMID: 11743226.

Sabbatini M1, Tomassoni D, Di Tullio MA, Amenta F. Neuroprotective effect of treatment with calcium antagonists on hypertensive retina. Clin Exp Hypertens. 2002 Oct-Nov;24(7-8):727-40. PMID: 12450247.

Martinez ML1, Lopes LF, Coelho EB, et al. Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension. J Cardiovasc Pharmacol. 2006 Jan;47(1):117-22. PMID: 16424795.

Bastos MF1, Vasconcelos de Araújo I, et al. Effects of lercanidipine on bone density and bone repair in spontaneously hypertensive rats. Implant Dent. 2013 Feb;22(1):49-54. doi: 10.1097/ID.0b013e3182777650. PMID: 23287976.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P6818

    Prednisolone

    Cortisol derivative; glucocorticoid agonist.

    ≥98%
  • W317520

    WIN 55,212-2 Mesylate

    Non-selective cannabinoid receptor agonist.

    ≥98%
  • P8118

    Puerarin

    Isoflavone daidzein derivative found in Puerari...

    ≥96%
  • S8245

    Sulfadiazine

    Sulfonamide; folate production inhibitor.

    ≥98%
  • A5315

    Deoxyandrographolide

    Labdane diterpene found in Andrographolis; cNOS...

    ≥98%
  • H3277

    Histrelin Acetate

    Peptide, GnRH analog; GnRH agonist.
    ≥95%
  • T1030

    N-Des-2-methylpropan-2-ol Docetaxel

    N-Des-2-methylpropan-2-ol Docetaxel is an impur...

    ≥90%
  • G0247

    2″O-Galloylhyperin

    Flavonoid glycoside found in Pyrola.

    ≥98%
  • S1604

    Secretin Acetate

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • A7460

    Asparaginase

    Catalyzes hydrolysis of asparagine.

    ≥98%
  • B3358

    Biochanin A

    Phytoestrogen, flavonoid found in clover, soy, ...

    ≥98%
  • G4535

    Glimepiride

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • G720009

    GS-9901

    Selective inhibitor of the delta isoform of PI3...

    ≥99%
  • B3374

    Bisacodyl

    Diphenylmethane derivative, stimulates colonic ...

    ≥98%
  • U698576

    Urolithin B

    Ellagic acid derivative produced by gut microfl...

    ≥99%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • I7557

    1-Isothiocyanato-6-(methylsulfonyl)-hexane

    Synthetic ITC, erysolin analog.

    ≥98%
  • P7628

    Parathyroid Hormone-Related Protein (1-34), human/rat

    Endogenous peptide hormone, increases extracell...

    ≥95%
  • V3327

    Virginiamycin Mixture

    Macrolide antibiotic

    ≥97%
  • P3456

    Pimobendan

    PDE3 inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only