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Lofexidine is an agonist at α2-adrenergic receptors that exhibits antihypertensive activity. Lofexidine is currently under examination as a treatment of opioid withdrawal. In animal models, lofexidine inhibits stress-induced reinstatement and self-administration of drug use.
| Cas No. | 21498-08-8 |
|---|---|
| Purity | ≥98% |
| Formula | C11H12Cl2N2O • HCl |
| Formula Wt. | 295.60 |
| Chemical Name | 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H- imidazole hydrochloride |
| IUPAC Name | 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride |
| Synonym | Lofetensin, Loxacor |
| Melting Point | 230-232°C |
| Solubility | Soluble in water and ethanol. Slightly soluble in 2-propanol. Practically insoluble in ether. |
| Appearance | White or off white powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Gowing L, Farrell MF, Ali R, et al. Alpha2-adrenergic agonists for the management of opioid withdrawal. Cochrane Database Syst Rev. 2014 Mar 31;3:CD002024. PMID: 24683051.
Lê AD, Harding S, Juzytsch W, et al. Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats. Psychopharmacology (Berl). 2005 May;179(2):366-73. PMID: 15551068.