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Lopinavir

Lopinavir

Product ID L5862
Cas No. 192725-17-0
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $90.30 In stock
500 mg $188.70 In stock
1 g $251.50 In stock
5 g $956.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lopinavir is an HIV protease inhibitor that displays antiviral and anticancer activities. In vitro, lopinavir inhibits sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), decreasing intracellular Ca2+ levels. In vivo, lopinavir’s inhibition of SERCA induces endoplasmic reticulum stress. In human papilloma virus (HPV)-positive cervical cancer cells, lopinavir upregulates ribonuclease L protein (RNASEL), potentially inducing cell death. In meningioma cells, lopinavir induces cell cycle arrest and inhibits cell growth.

Product Info

Cas No.

192725-17-0

Purity

≥98%

Formula

C37H48N4O5

Formula Wt.

628.81

Chemical Name

(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide

IUPAC Name

(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1, 6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide InChI: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21- 28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26 (3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38, 45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

Synonym

Aluviran, Kaletra

Solubility

DMSO to 126 mg/mL, ethanol to 126 mg/mL, ethyl acetate

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

L5862 MSDS PDF

Info Sheet

L5862 Info Sheet PDF

Brochures

Antivirals Booklet

References

Kao E, Shinohara M, Feng M, et al. Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology. 2012 Aug;56(2):594-604. PMID: 22407670.

Batman G, Oliver AW, Zehbe I, et al. Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells. Antivir Ther. 2011;16(4):515-25. PMID: 21685539.

Johnson MD, O'Connell M, Pilcher W. Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism. J Neurooncol. 2011 Feb;101(3):441-8. PMID: 20596751.

Custom Order

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