Lopinavir

Name: Lopinavir
SKU: L5862
Availability: InStock

Product ID L5862

Cas No. 192725-17-0

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Lopinavir is an HIV protease inhibitor that displays antiviral and anticancer activities. In vitro, lopinavir inhibits sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), decreasing intracellular Ca2+ levels. In vivo, lopinavir’s inhibition of SERCA induces endoplasmic reticulum stress. In human papilloma virus (HPV)-positive cervical cancer cells, lopinavir upregulates ribonuclease L protein (RNASEL), potentially inducing cell death. In meningioma cells, lopinavir induces cell cycle arrest and inhibits cell growth.

Product Info

Cas No.	192725-17-0
Purity	≥98%
Formula	C₃₇H₄₈N₄O₅
Formula Wt.	628.81
Chemical Name	(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
IUPAC Name	(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1, 6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide InChI: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21- 28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26 (3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38, 45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
Synonym	Aluviran, Kaletra
Solubility	DMSO to 126 mg/mL, ethanol to 126 mg/mL, ethyl acetate
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	L5862 MSDS PDF
Info Sheet	L5862 Info Sheet PDF
Brochures	Antivirals Booklet

References

Kao E, Shinohara M, Feng M, et al. Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology. 2012 Aug;56(2):594-604. PMID: 22407670.

Batman G, Oliver AW, Zehbe I, et al. Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells. Antivir Ther. 2011;16(4):515-25. PMID: 21685539.

Johnson MD, O'Connell M, Pilcher W. Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism. J Neurooncol. 2011 Feb;101(3):441-8. PMID: 20596751.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Lopinavir

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Retinyl Acetate

Anisomycin

Ionomycin, Free Acid

Men 10376

Diclofenac Sodium

Kahweol Stearate

6-Mercaptopurine Monohydrate

P7C3

Rapamycin

Cilostazol

BMS-911543

K252a

Sesamin

Biotin

7-Methyl-6-mercaptopurine

Fibrinogen γ-chain Dodecapeptide

Angiotensin II (4-8), human

Latrunculin A

Luteinizing Hormone Releasing Hormone, salmon

Geldanamycin

Footer