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Luteinizing Hormone Releasing Hormone

Luteinizing Hormone Releasing Hormone

Product ID L8276
Cas No. 9034-40-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $81.70 In stock
2 mg $138.90 Please Inquire
5 mg $245.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Luteinizing hormone-releasing hormone (LHRH or Gonadotropin-releasing hormone [GnRH]) is an endogenous peptide hormone that binds the GnRH receptor, stimulating secretion of reproductive hormones (such as luteinizing hormone [LH
] and follicle-stimulating hormone [FSH]) from the pituitary gland. Analogs of GnRH are clinically used to treat hormone-dependent diseases such as prostate and breast cancer, hyperplasia, and endometriosis.

Product Info

Cas No.

9034-40-6

Purity

≥98%

Formula

C55H76N17O13

Formula Wt.

1182.3

IUPAC Name

N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl] pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4- methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1- oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3- yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5- oxopyrrolidine-2-carboxamide

Synonym

LHRH, Gonadoliberin, Luliberin, Nialutin

Solubility

Soluble in 5% acetic acid.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L8276 MSDS PDF

Info Sheet

L8276 Info Sheet PDF

References

Limonta P, Manea M. Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies. Cancer Treat Rev. 2013 Oct;39(6):647-63. PMID: 23290320.

Millar RP, Newton CL. Current and future applications of GnRH, kisspeptin and neurokinin B analogues. Nat Rev Endocrinol. 2013 Aug;9(8):451-66. PMID: 23817290.

Wu HM, Wang HS, Huang HY, et al. Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2. BMC Cancer. 2013 Jun 20;13:300. PMID: 23786715.

Burel D, Li JH, Do-Rego JL, et al. Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus. Endocrinology. 2013 Jun;154(6):2114-28. PMID: 23554453.

Custom Order

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