LY-294002 Hydrochloride

Name: LY-294002 Hydrochloride
SKU: L960002
Availability: InStock

Product ID L960002

Cas No. 934389-88-5

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Water soluble form of LY-294002 (L4796). LY-294002 is an inhibitor of PI3K that is used to sensitize cancer cells to other co-administered anticancer chemotherapeutics. In macrophages and monocytes, LY-294002 inhibits NF-κB activity and decreases levels of p50 NF-κB; it also inhibits LPS-induced expression of IL-10. LY-294002 prevents ruffled border formation in osteoclasts by altering the binding of acidic vacuoles with the intercellular membrane. Additionally, this compound inhibits DNA-dependent protein kinase (DPK) activity and prevents the formation of NO.

Product Info

Cas No.	934389-88-5
Purity	≥98%
Formula	C₁₉H₁₇NO₃ • HCl
Formula Wt.	343.81
IUPAC Name	2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-one hydrochloride (1:1)
Synonym	LY294002 HCl

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	L960002 MSDS PDF
Info Sheet	L960002 Info Sheet PDF

References

Avni D, Glucksam Y, Zor T. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism. Biochem Pharmacol. 2012 Jan 1;83(1):106-14. PMID: 22005520.

Salh B, Wagey R, Marotta A, et al. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J Immunol. 1998 Dec 15;161(12):6947-54. PMID: 9862729.

Nakamura I, Sasaki T, Tanaka S, et al. Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts. J Cell Physiol. 1997 Aug;172(2):230-9. PMID: 9258344.

Rosenzweig KE, Youmell MB, Palayoor ST, et al. Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res. 1997 Jul;3(7):1149-56. PMID: 9815794.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

LY-294002 Hydrochloride

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

1-Isothiocyanato-6-(methylsulfenyl)-hexane

Recombinant M. Tuberculosis Antigen TB 38+6+10

Cephalomannine

Mitomycin C

Nifedipine

L-(+)-Selenomethionine

STING Agonist-12

S-(+)-α−Methylbenzyl Isothiocyanate

Substance P (1-7)

Urolithin B

Gallocatechin Gallate

GLYX-13 Trifluoroacetate

Endothelin-3, human

Nizatidine

GDC-1971

H-151

Leupeptin Hemisulfate

Splitomicin

Ractopamine Hydrochloride

PIK-294

Footer