• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
LY-3214996

LY-3214996

Product ID L960012
Cas No. 1951483-29-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $136.30 In stock
25 mg $340.70 In stock
100 mg $885.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY-3214996 is a selective inhibitor of ERK1/2. ERK1/2 inhibitors offer a targeted approach to cancers in which the RAS/MAPK signaling pathway is dysregulated. These compounds can be successful when Braf and MEK inhibitor efficacy is lost due to developed drug resistance. LY-3214996 has demonstrated potent antitumor effects in several human cancer xenograft models, including Braf or Kras mutant colorectal, lung, and pancreatic cancer models.

Product Info

Cas No.

1951483-29-6

Purity

≥98%

Formula

C22H27N7O2S

Formula Wt.

453.57

Chemical Name

6,6-dimethyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5-(2-morpholin-4-ylethyl)thieno[2,3-c]pyrrol-4-one

IUPAC Name

6,6-Dimethyl-2-{2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl}-5-[2-(4-morpholinyl)ethyl]-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one

Synonym

LY 3214996, LY3214996

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L960012 MSDS PDF

Info Sheet

L960012 Info Sheet PDF

References

Gaiying Z., McMillen W., et al. Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996. Cancer Res. 77(13 Suppl.):3231 (2017).

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T3032

    Thienyldecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥95%
  • H1894

    Hexestrol

    Synthetic catechol; ER agonist, microtubule pol...

    ≥98%
  • D3221

    Difluoromethylornithine Hydrochloride Monohydrate

    Ornithine decarboxylase inhibitor.

    ≥98%
  • R1626

    Regorafenib Monohydrate

    VEGFR1/2/3, TIE2, PDGFRβ, FGFR1, c-Kit, RET, B...

    ≥99%
  • C0168

    Canthaxanthin

    Carotenoid terpene pigment found in various pla...

    ≥9% (product contains stabilizers)
  • D1776

    Desmopressin

    Synthetic vasopressin derivative; V2R agonist.<...

    ≥95%
  • M3577

    Mitiglinide Calcium

    ATP-sensitive K+ channel blocker, potential RyR...

    ≥98%
  • X0384

    XAV-939

    Tankyrase inhibitor.

    ≥98%
  • E9317

    Exemestane

    Aromatase inhibitor.

    ≥97%
  • P0006

    Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • O9302

    Oxacillin Sodium Monohydrate

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • D3208

    Diclazuril

    Coccidiostat, GAPDH inhibitor.

    ≥98%
  • Q8139

    Quizartinib

    FLT3, c-Kit, PDGFR inhibitor.

    ≥98%
  • T3197

    L-Thyroxine Sodium Pentahydrate

    Endogenous thyroid hormone T4.

    ≥97%
  • G1658

    Gentamycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

  • H014458

    Halometasone

    Glucocorticoid

    ≥98%
  • R0349

    Ramosetron

    5-HT3 antagonist.

    ≥99%
  • U6956

    Uroguanylin, human

    Endogenous peptide, involved in water/Na+ homeo...

    ≥95%
  • T1006

    10-Acetoacetyl Paclitaxel

    Synthesis impurity

    ≥95%
  • T286165

    Theaflavin-3-gallate

    Polyphenolic compound present in black tea.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only