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LY-3214996

LY-3214996

Product ID L960012
Cas No. 1951483-29-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $136.30 In stock
25 mg $340.70 In stock
100 mg $885.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY-3214996 is a selective inhibitor of ERK1/2. ERK1/2 inhibitors offer a targeted approach to cancers in which the RAS/MAPK signaling pathway is dysregulated. These compounds can be successful when Braf and MEK inhibitor efficacy is lost due to developed drug resistance. LY-3214996 has demonstrated potent antitumor effects in several human cancer xenograft models, including Braf or Kras mutant colorectal, lung, and pancreatic cancer models.

Product Info

Cas No.

1951483-29-6

Purity

≥98%

Formula

C22H27N7O2S

Formula Wt.

453.57

Chemical Name

6,6-dimethyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5-(2-morpholin-4-ylethyl)thieno[2,3-c]pyrrol-4-one

IUPAC Name

6,6-Dimethyl-2-{2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl}-5-[2-(4-morpholinyl)ethyl]-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one

Synonym

LY 3214996, LY3214996

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L960012 MSDS PDF

Info Sheet

L960012 Info Sheet PDF

References

Gaiying Z., McMillen W., et al. Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996. Cancer Res. 77(13 Suppl.):3231 (2017).

Custom Order

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