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LY-450139

LY-450139

Product ID L9701
Cas No. 425386-60-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $127.90 In stock
25 mg $413.30 In stock
50 mg $721.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY-450139 is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective activity. LY-450139 displays mixed results in clinical trials as a potential treatment for Alzheimer’s disease. This compound also increases glutamate in the prefrontal cortex when administered chronically and activates growth hormone secretagogue receptor GHS-R1a.

Product Info

Cas No.

425386-60-3

Purity

≥98%

Formula

C19H27N3O4

Formula Wt.

361.44

IUPAC Name

(2S)-2-Hydroxy-3-methyl-N-[(2S)-1-{[(1S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl]amino}-1-oxo-2-propanyl]butanamide

Synonym

Semagacestat; LY450139; LY 450139

Solubility

DMSO 72 mg/mL (199.2 mM) Ethanol 41 mg/mL (113.43 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L9701 MSDS PDF

Info Sheet

L9701 Info Sheet PDF

References

Beggiato S, Giuliani A, Sivilia S, et al. CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice. Neuroscience. 2014 Apr 25;266:13-22. PMID: 24530449.

Doody RS, Raman R, Farlow M, et al. A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N Engl J Med. 2013 Jul 25;369(4):341-50. PMID: 23883379.

Schellekens H, McNamara O, Dinan TG, et al. Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor. J Pharm Pharmacol. 2013 Apr;65(4):528-38. PMID: 23488781.

Custom Order

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