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Magnolol

Magnolol

Product ID M0125
Cas No. 528-43-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $81.20 In stock
25 mg $168.40 In stock
100 mg $561.40 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Magnolol is a lignan originally found in Magnolia bark that exhibits neuromodulatory, cognition enhancing, antimicrobial, anti-osteoporotic, anti-diabetic, anti-hyperlipidemic, anticancer, anti-inflammatory, antioxidative, neuroprotective, and anti-angiogenic activities. Magnolol potentiates activity at GABA-A receptors and inhibits scopolamine-induced oxidative dysfunction and learning and memory deficits in animal models of Alzheimer’s disease. Magnolol also displays antifungal activity against Trichophyton, Microsporium, Epidermophyton, Aspergillus, Candida, and Cryptococcus. Additionally, this compound increases growth, collagen synthesis, and mineralization in osteoblasts while decreasing differentiation and inflammatory cytokine expression. In diabetic animal models, magnolol inhibits oxidative damage and decreases serum levels of glucose and lipids. In breast cancer cells, magnolol downregulates expression of matrix metalloproteinase 9 (MMP9) and inhibits activation of NF-κB, suppressing invasion. Magnolol inhibits tube formation, vessel sprouting, and migration in other cellular models. In macrophages, this compound downregulates LPS-stimulated expression of toll-like receptor 4 (TLR4), IL-6, TNF-α, and IL-1β.

Product Info

Cas No.

528-43-8

Purity

≥98%

Formula

C18H18O2

Formula Wt.

266.34

Chemical Name

5,5'-Di-2-propenyl-[1,1'-biphenyl]-2,2'-diol

IUPAC Name

2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol

Synonym

Dehydrodichavicol

Melting Point

101.5-102°C

Solubility

Soluble in ethanol.

Appearance

White to light yellow fine powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

M0125 MSDS PDF

Info Sheet

M0125 Info Sheet PDF

References

Wang JJ, Zhao R, Liang JC, et al. The antidiabetic and hepatoprotective effects of magnolol on diabetic rats induced by high-fat diet and streptozotocin. Yao Xue Xue Bao. 2014 Apr;49(4):476-81. PMID: 24974464.

Liu Y, Cao W, Zhang B, et al. The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy. Sci Rep. 2013 Nov 14;3:3098. PMID: 24226295.

Kim KM, Kim NS, Kim J, et al. Magnolol suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways. Nutr Cancer. 2013;65(8):1245-53. PMID: 24066970.

Li YS, Hong YF, He J, et al. Effects of magnolol on impairment of learning and memory abilities induced by scopolamine in mice. Biol Pharm Bull. 2013;36(5):764-71. PMID: 23445942.

Fu Y, Liu B, Zhang N, et al. Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways. J Ethnopharmacol. 2013 Jan 9;145(1):193-9. PMID: 23127653.

Kwak EJ, Lee YS, Choi EM. Effect of magnolol on the function of osteoblastic MC3T3-E1 cells. Mediators Inflamm. 2012;2012:829650. PMID: 22474400.

Ai J, Wang X, Nielsen M. Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro. Pharmacology. 2001 Jul;63(1):34-41. PMID: 11408830.

Bang KH, Kim YK, Min BS, et al. Antifungal activity of magnolol and honokiol. Arch Pharm Res. 2000 Feb;23(1):46-9. PMID: 10728656.

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