LKT Labs

Biochemicals for Life Science Research

Maprotiline Hydrochloride

Maprotiline Hydrochloride

Product ID M0262
Cas No. 10347-81-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $61.00 In stock
5 g $245.00 In stock
Bulk Quote

Quicklinks

Description

Maprotiline is a tetracyclic antidepressant that also exhibits sedative, anxiolytic, sympathomimetic, and anticancer activities. Maprotiline acts as an antagonist at norepinephrine transporters (NET), H1 histamine receptors, 5-HT2 receptors, α1-adrenergic receptors, muscarinic acetylcholine receptors (mAChRs), and L-type Ca2+ channels. Maprotiline induces caspase-mediated apoptosis in neuroblastoma cells, inhibiting cell viability in a JNK- and ERK-dependent manner. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

10347-81-6
Purity

≥98%
Formula

C20H23N • HCl
Formula Wt.

313.87
Chemical Name

N-Methyl-9.10-ethanoanthracene-9(10H)-propanamine hydrochloride
IUPAC Name

N-methyl-3-(1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl)propan-1-amine;hydrochloride
Synonym

Deprilept, Ludiomil, Psymion
Melting Point

230-232°C

Solubility

Soluble in methanol and chloroform. Slightly soluble in water.

Appearance

A White or Almost White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

M0262 MSDS PDF
Info Sheet

M0262 Info Sheet PDF

References

Jan CR, Su JA, Teng CC, et al. Mechanism of maprotiline-induced apoptosis: role of [Ca2+](i), ERK, JNK and caspase-3 signaling pathways. Toxicology. 2013 Feb 8;304:1-12. PMID: 23219590.

Zahradník I, Minarovic I, Zahradníková A. Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. J Pharmacol Exp Ther. 2008 Mar;324(3):977-84. PMID: 18048694.

Mayers AG, Baldwin DS. Antidepressants and their effect on sleep. Hum Psychopharmacol. 2005 Dec;20(8):533-59. PMID: 16229049.

Muscat R, Papp M, Willner P. Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline. Psychopharmacology (Berl). 1992;109(4):433-8. PMID: 1365858.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5276

    Angiotensin I, human

    Endogenous peptide, cleavage product of angiote...

    ≥98%
  • T1670

    Terazosin Hydrochloride Dihydrate

    Quinazoline; α1-adrenergic antagonist.

    ≥98%
  • U482046

    (-)-Umbellulone

    Antimicrobial found in essential oils from plan...

    ≥98%
  • G124090

    GDC-6036

    KRAS inhibitor

    ≥98%
  • P1754

    Penciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • M9608

    Myclobutanil

    14-α demethylase inhibitor.

    ≥97%
  • N3346

    Nilotinib

    Phenylamino pyridine; Abl, c-Kit, PDGFR, PP2A i...

    ≥99%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • A0248

    BAM-12P

    Peptide, cleavage product of proenkephalin; κO...

    ≥95%
  • C0044

    CAL101

    p110δ PI3K inhibitor.

    ≥99%
  • R0105

    Rabeprazole Sodium

    H+/K+ ATPase and Scpc phosphatase inhibitor.

    ≥98%
  • A6800

    AR-A014418

    GSK-3β inhibitor.

    ≥98%
  • F465817

    Flunisolide

    Corticosteroid

    ≥90%
  • A9978

    Aztreonam

    β-lactam; penicillin binding protein inhibitor...

    ≥96%
  • G3462

    Ginsenoside F3

    Triterpene saponin found in species of Panax.

    ≥98%
  • K0031

    Kahweol Acetate

    Diterpene found in coffee beans.

    ≥98%
  • R2711

    Recombinant HCV-Core Antigens

    Recombinant HIV core protein antigen fragment.<...

    ≥95%
  • S2957

    Shogaol

    Phenol found in Zingiber; PPARγ agonist, 5-HT3...

    ≥98%
  • N3301

    Niacin

    Vitamin B, required for formation of NAD and NA...

    ≥98%
  • L5769

    Lorglumide Sodium

    CCK antagonist.

    ≥98%