Maprotiline Hydrochloride

Name: Maprotiline Hydrochloride
SKU: M0262
Availability: InStock

Product ID M0262

Cas No. 10347-81-6

Purity ≥98%

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Description

Maprotiline is a tetracyclic antidepressant that also exhibits sedative, anxiolytic, sympathomimetic, and anticancer activities. Maprotiline acts as an antagonist at norepinephrine transporters (NET), H1 histamine receptors, 5-HT2 receptors, α1-adrenergic receptors, muscarinic acetylcholine receptors (mAChRs), and L-type Ca2+ channels. Maprotiline induces caspase-mediated apoptosis in neuroblastoma cells, inhibiting cell viability in a JNK- and ERK-dependent manner. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	10347-81-6
Purity	≥98%
Formula	C₂₀H₂₃N • HCl
Formula Wt.	313.87
Chemical Name	N-Methyl-9.10-ethanoanthracene-9(10H)-propanamine hydrochloride
IUPAC Name	N-methyl-3-(1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl)propan-1-amine;hydrochloride
Synonym	Deprilept, Ludiomil, Psymion
Melting Point	230-232°C
Solubility	Soluble in methanol and chloroform. Slightly soluble in water.
Appearance	A White or Almost White Crystalline Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	M0262 MSDS PDF
Info Sheet	M0262 Info Sheet PDF

References

Jan CR, Su JA, Teng CC, et al. Mechanism of maprotiline-induced apoptosis: role of [Ca2+](i), ERK, JNK and caspase-3 signaling pathways. Toxicology. 2013 Feb 8;304:1-12. PMID: 23219590.

Zahradník I, Minarovic I, Zahradníková A. Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. J Pharmacol Exp Ther. 2008 Mar;324(3):977-84. PMID: 18048694.

Mayers AG, Baldwin DS. Antidepressants and their effect on sleep. Hum Psychopharmacol. 2005 Dec;20(8):533-59. PMID: 16229049.

Muscat R, Papp M, Willner P. Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline. Psychopharmacology (Berl). 1992;109(4):433-8. PMID: 1365858.

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Maprotiline Hydrochloride

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Description

Product Info

Shipping and Storage

Downloads

References

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