• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Masitinib

Masitinib

Product ID M0374
Cas No. 790299-79-5
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $75.10 In stock
25 mg $225.40 In stock
100 mg $721.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Masitinib is an anticancer chemotherapeutic and anti-inflammatory compound used in veterinary medicine. Masitinib inhibits c-Kit and PDGFR, increasing survival time in the treatment of mast cell tumors and other cancers. In vitro, masitinib increases levels of caspases 3 and 7, inducing apoptosis. Masitinib also decreases airway inflammation and edema in feline allergic asthma models and also decreases the patient-rated severity of multiple sclerosis in clinical settings. Masitinib also exhibits potential efficacy against Alzheimer’s disease when given as an adjunct therapy, slowing cognitive decline.

Product Info

Cas No.

790299-79-5

Purity

≥99%

Formula

C28H30N6OS

Formula Wt.

498.64

Chemical Name

4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide

IUPAC Name

4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1, 3-thiazol-2-yl)amino]phenyl]benzamide

Synonym

AB1010; Masatinib; Masitinib (AB1010); Masivet 

Appearance

Gray to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M0374 MSDS PDF

Info Sheet

M0374 Info Sheet PDF

References

Smrkovski OA, Essick L, Rohrbach BW, et al. Masitinib mesylate for metastatic and non-resectable canine cutaneous mast cell tumours. Vet Comp Oncol. 2013 Jul 12. [Epub ahead of print]. PMID: 23845124.

Fahey CE, Milner RJ, Kow K, et al. Apoptotic effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine osteosarcoma cells. Anticancer Drugs. 2013 Jun;24(5):519-26. PMID: 23466652.

Vermersch P, Benrabah R, Schmidt N, et al. Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study. BMC Neurol. 2012 Jun 12;12:36. PMID: 22691628.

Lee-Fowler TM, Guntur V, Dodam J, et al. The tyrosine kinase inhibitor masitinib blunts airway inflammation and improves associated lung mechanics in a feline model of chronic allergic asthma. Int Arch Allergy Immunol. 2012;158(4):369-74. PMID: 22487554.

Cadot P, Hensel P, Bensignor E, et al. Masitinib decreases signs of canine atopic dermatitis: a multicentre, randomized, double-blind, placebo-controlled phase 3 trial. Vet Dermatol. 2011 Dec;22(6):554-64. PMID: 21668810.

Piette F, Belmin J, Vincent H, et al. Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial. Alzheimers Res Ther. 2011 Apr 19;3(2):16. PMID: 21504563.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S3449

    Simvastatin

    Statin; HMG-CoA reductase inhibitor, potential ...

    ≥98%
  • T1673

    Terlipressin Acetate

    Synthetic peptide, vasopressin analog; AVPR1 ag...

    ≥95%
  • F3454

    Fingolimod Hydrochloride

    Sphingosine 1-phosphate antagonist.

    ≥99%
  • A4547

    Alloxan Monohydrate

    Pyrimidine, glucose analog, used to induce diab...

    ≥98%
  • L0209

    Lactoferrin, cow

    Endogenous glycoprotein; lactoferrin agonist.

    ≥92%
  • O4578

    Oltipraz

    Antioxidant; Nrf2 activator.

    ≥98%
  • G1869

    Geranylgeraniol

    Diterpene alcohol, geranylgeranyl pyrophosphate...

    ≥85%
  • A4940

    6-Aminonicotinamide

    G6PDH inhibitor.

    ≥98%
  • T0120

    2′,7-bis(triethylsilyl)taxol

    Synthesis intermediate

    ≥98%
  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%
  • P2515

    3-Phenylpropyl Isothiocyanate

    Synthetic ITC.

    ≥98%
  • S7870

    Streptozocin

    Nitrosourea-amino sugar conjugate, DNA cross-li...

    ≥98%
  • K7602

    KT5823

    PKG inhibitor.

    ≥98%
  • U6957

    Urotensin I

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • C5654

    Concanavalin A

    Lectin found in Canavelia, plant mitogen that b...

  • B1879

    Betamethasone Valerate

    Synthetic steroid hormone; glucocorticoid agoni...

    ≥98%
  • T8020

    Tuftsin

    Tetrapeptide, IgG Fc region derivative; Nrp1 ag...

    ≥95%
  • B3275

    Bis(3,5-dibromosalicyl) Succinate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥95%
  • C104762

    CCT-245737

    CHK1 inhibitor.

    ≥98%
  • C344761

    Citalopram Chloromethyl Quaternary Ammonium Chloride

    Citalopram analog

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only