Masitinib

Name: Masitinib
SKU: M0374
Availability: InStock

Product ID M0374

Cas No. 790299-79-5

Purity ≥99%

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Description

Masitinib is an anticancer chemotherapeutic and anti-inflammatory compound used in veterinary medicine. Masitinib inhibits c-Kit and PDGFR, increasing survival time in the treatment of mast cell tumors and other cancers. In vitro, masitinib increases levels of caspases 3 and 7, inducing apoptosis. Masitinib also decreases airway inflammation and edema in feline allergic asthma models and also decreases the patient-rated severity of multiple sclerosis in clinical settings. Masitinib also exhibits potential efficacy against Alzheimer’s disease when given as an adjunct therapy, slowing cognitive decline.

Product Info

Cas No.	790299-79-5
Purity	≥99%
Formula	C₂₈H₃₀N₆OS
Formula Wt.	498.64
Chemical Name	4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
IUPAC Name	4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1, 3-thiazol-2-yl)amino]phenyl]benzamide
Synonym	AB1010; Masatinib; Masitinib (AB1010); Masivet
Appearance	Gray to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

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MSDS	M0374 MSDS PDF
Info Sheet	M0374 Info Sheet PDF

References

Smrkovski OA, Essick L, Rohrbach BW, et al. Masitinib mesylate for metastatic and non-resectable canine cutaneous mast cell tumours. Vet Comp Oncol. 2013 Jul 12. [Epub ahead of print]. PMID: 23845124.

Fahey CE, Milner RJ, Kow K, et al. Apoptotic effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine osteosarcoma cells. Anticancer Drugs. 2013 Jun;24(5):519-26. PMID: 23466652.

Vermersch P, Benrabah R, Schmidt N, et al. Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study. BMC Neurol. 2012 Jun 12;12:36. PMID: 22691628.

Lee-Fowler TM, Guntur V, Dodam J, et al. The tyrosine kinase inhibitor masitinib blunts airway inflammation and improves associated lung mechanics in a feline model of chronic allergic asthma. Int Arch Allergy Immunol. 2012;158(4):369-74. PMID: 22487554.

Cadot P, Hensel P, Bensignor E, et al. Masitinib decreases signs of canine atopic dermatitis: a multicentre, randomized, double-blind, placebo-controlled phase 3 trial. Vet Dermatol. 2011 Dec;22(6):554-64. PMID: 21668810.

Piette F, Belmin J, Vincent H, et al. Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial. Alzheimers Res Ther. 2011 Apr 19;3(2):16. PMID: 21504563.

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Masitinib

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