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Melittin

Melittin

Product ID M1744
Cas No. 20449-79-0
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $220.50 In stock
1 mg $393.80 In stock
2.5 mg $682.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Melittin is an antimicrobial peptide (AMP) found in Apis mellifera venom that exhibits antifungal, antibacterial, antiviral, and anti-parasitic activities. In Candida, melittin increases formation of radicals, decreases the mitochondrial membrane potential, and increases release of Ca2+ from the endoplasmic reticulum, inducing apoptosis and death. Like other AMPs, melittin induces pore formation in cell membranes, causing ion leakage. Melittin exhibits antimicrobial activity against Leishmania and Trypanosoma, inducing autophagy and apoptosis.

Product Info

Cas No.

20449-79-0

Purity

≥95%

Formula

C131H229N39O31

Formula Wt.

2846.5

Synonym

Mellitin, Melitten I, Forapin

Solubility

Soluble in water (5 mg/mL) or PBS (5 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M1744 MSDS PDF

Info Sheet

M1744 Info Sheet PDF

References

Lee J, Lee DG. Melittin triggers apoptosis in Candida albicans through the reactive oxygen species-mediated mitochondria/caspase-dependent pathway. FEMS Microbiol Lett. 2014 Apr 27. [Epub ahead of print]. PMID: 24766524.

Lee MT, Sun TL, Hung WC, et al. Process of inducing pores in membranes by melittin. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14243-8. PMID: 23940362.

Adade CM, Oliveira IR, Pais JA, et al. Melittin peptide kills Trypanosoma cruzi parasites by inducing different cell death pathways. Toxicon. 2013 Jul;69:227-39. PMID: 23562368.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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