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Methylprednisolone

Methylprednisolone

Product ID M1877
Cas No. 83-43-2
Purity ≥96%
Product Unit SizeCostQuantityStock
100 mg $116.00 In stock
500 mg $350.80 In stock
1 g $598.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Methylprednisolone is a synthetic glucocorticoid that displays anti-inflammatory and immunosuppressive activities. In vitro, methylprednisolone decreases survival of activated CD4+ T cells. In glioblastoma cells, this compound inhibits oxidative stress-induced apoptosis. Additionally, methylprednisolone decreases infiltration of immune cells and suppresses release of inflammatory cytokines in animal models of inflammation.

Product Info

Cas No.

83-43-2

Purity

≥96%

Formula

C22H30O5

Formula Wt.

374.47

Chemical Name

(6α,11β)-11,17,21-Trihydroxy-6-methylpregna-1,4- diene-3,20-dione

IUPAC Name

(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6, 10,13-trimethyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Synonym

Medrate, Medrol, Medrone, Urbason

Melting Point

228-237°C

Solubility

Slightly soluble in ethanol (10 mg/mL), dioxane, acetone, or chloroform. Insoluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

M1877 MSDS PDF

Info Sheet

M1877 Info Sheet PDF

References

Lu YS, Pu LY, Li XC, et al. Methylprednisolone inhibits activated CD4+ T cell survival promoted by toll-like receptor ligands. Hepatobiliary Pancreat Dis Int. 2010 Aug;9(4):376-83. PMID: 20688601.

Das A, Banik NL, Ray SK. Methylprednisolone and indomethacin inhibit oxidative stress mediated apoptosis in rat C6 glioblastoma cells. Neurochem Res. 2007 Nov;32(11):1849-56. PMID: 17570061.

Sloka JS, Stefanelli M. The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler. 2005 Aug;11(4):425-32. PMID: 16042225.

Custom Order

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