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Mitotane

Mitotane

Product ID M3576
Cas No. 53-19-0
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $72.90 In stock
500 mg $145.80 In stock
1 g $246.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mitotane is an anticancer chemotherapeutic compound clinically used to treat adrenocortical carcinoma, as it targets only adrenal cells and not others. In adrenocortical cells, mitotane inhibits secretion of cortisol and 17-hydroxyprogesterone and decreases activity of cytochrome c oxidase, suppressing mitochondrial respiration and inhibiting cell proliferation. Mitotane may induce hyperlipidemia in clinical subjects, as it increases serum levels of LDL, HDL, and triglycerides.

Product Info

Cas No.

53-19-0

Purity

≥98%

Formula

C14H10Cl4

Formula Wt.

320.04

IUPAC Name

1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene

Melting Point

76-78C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M3576 MSDS PDF

Info Sheet

M3576 Info Sheet PDF

References

Shawa H, Deniz F, Bazerbashi H, et al. Mitotane-induced hyperlipidemia: a retrospective cohort study. Int J Endocrinol. 2013;2013:624962. PMID: 24348556.

Hescot S, Slama A, Lombès A, et al. Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells. Endocr Relat Cancer. 2013 May 21;20(3):371-81. PMID: 23696597.

Fang VS. Cytotoxic activity of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (mitotane) and its analogs on feminizing adrenal neoplastic cells in culture. Cancer Res. 1979 Jan;39(1):139-45. PMID: 761184.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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