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Mizoribine Hydrobromide

Mizoribine Hydrobromide

Product ID M3598
Cas No. 50924-49-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $142.90 In stock
25 mg $245.30 In stock
100 mg $959.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mizoribine is an inhibitor of inosine monophosphate dehydrogenase (IMPDH) that exhibits immunosuppressive and, potentially, antifungal activities. Mizoribine is used clinically in organ transplantations and to treat rheumatoid arthritis and lupus. In synovial cells, mizoribine decreases levels of IL-6 and matrix metalloproteinase 1 (MMP1). Mizoribine also inhibits proliferation of mesangial cells, decreasing expression of cyclin D1, skp2, and CDK2; it also increases expression of p27. Additionally, this compound may decrease proliferation of species of Candida and Aspergillus.

Product Info

Cas No.

50924-49-7

Purity

≥98%

Formula

C9H13N3O6 • HBr

Formula Wt.

340.13

IUPAC Name

1-[(2R,3R,4S,5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4- carboxamide

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M3598 MSDS PDF

Info Sheet

M3598 Info Sheet PDF

References

Sugiyama E, Ikemoto M, Taki H, et al. Mizoribine, an inhibitor of inosine monophosphate dehydrogenase, inhibits interleukin-6 production by freshly prepared rheumatoid synovial cells. Mod Rheumatol. 2001 Mar;11(1):28-33. PMID: 24387017.

Liu S, Xie Y, Lv Y, et al. A novel target of mizoribine inhibiting mesangial cell proliferation: S phase kinase-associated protein 2. Am J Nephrol. 2010;32(5):447-55. PMID: 20924167.

Rodriguez-Suarez R, Xu D, Veillette K, et al. Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus. Chem Biol. 2007 Oct;14(10):1163-75. PMID: 17961828.

Zhong B, Tajima M, Takahara H, et al. Inhibitory effect of mizoribine on matrix metalloproteinase-1 production in synovial fibroblasts and THP-1 macrophages. Mod Rheumatol. 2005;15(4):264-8. PMID: 17029075.

Hedstrom L. IMP dehydrogenase: mechanism of action and inhibition. Curr Med Chem. 1999 Jul;6(7):545-60. PMID: 10390600.

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