LKT Labs

Biochemicals for Life Science Research

MLN8237

MLN8237

Product ID M4652
Cas No. 1028486-01-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $118.00 In stock
5 mg $219.00 In stock
10 mg $337.00 In stock
Bulk Quote

Quicklinks

Description

MLN8237 inhibits aurora kinase A (AurA) preventing mitotic spindle formation and proper completion of mitosis. MLN8237 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for multiple myeloma, non-Hodgkin’s lymphoma, and chronic lymphocytic leukemia (CLL). In bladder cancer cells, MLN8237 induces cell cycle arrest, aneuploidy, and apoptosis; in animal models of bladder cancer, this compound inhibits tumor growth. Additionally, MLN8237 inhibits tumor growth of neuroblastomas in vivo as well. In HUVECs, MLN8237 decreases tubule formation and inhibits VEGF secretion, suggesting potential anti-angiogenic activity.

Product Info

Cas No.

1028486-01-2
Purity

≥98%
Formula

C27H20ClFN4O4
Formula Wt.

518.92
IUPAC Name

4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid
Synonym

Alisertib
Solubility

DMSO 27 mg/mL (52.03 mM) Water Insoluble Ethanol Insoluble
Appearance

Pale Yellow Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

M4652 MSDS PDF
Info Sheet

M4652 Info Sheet PDF

References

Romain C, Paul P, Kim KW, et al. Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. J Pediatr Surg. 2014 Jan;49(1):159-65. PMID: 24439602.

Kelly KR, Shea TC, Goy A, et al. Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia. Invest New Drugs. 2013 Dec 20. [Epub ahead of print]. PMID: 24352795.

Zhou N, Singh K, Mir MC, et al. The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo. Clin Cancer Res. 2013 Apr 1;19(7):1717-28. PMID: 23403633.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P2012

    PF-04217903

    Triazolopyrazine; c-MET inhibitor.

    ≥98%
  • C8500

    CV-65

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • C5972

    Corynoline

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • T3032

    Thienyldecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥95%
  • R6052

    Recombinant Mycoplasma Pneumonia Antigen

    Pneumonia antigen
  • I2056

    Ifosfamide

    Nitrogen mustard, DNA alkylator.

    ≥98%
  • B349921

    BIX-01294

    Specific inhibitor of histone methyltransferase...

    ≥99%
  • C0021

    Cafestol Acetate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • T1853

    Tenovin-6

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • T0091

    7-(Triethylsilyl)-10-deacetylbaccatin III

    Taxol derivative.

    ≥97%
  • E5222

    Endothelin-3, human

    Endogenous peptide, involved in vascular contra...

    ≥95%
  • C9615

    Cyclosporin B

    Cyclic peptide; calcineurin inhibitor.

    ≥95%
  • A822686

    Aureothricin

    Aureothricin is a member of the dithiolopyrrolo...

    ≥98%
  • T3468

    Tirapazamine

    Topoisomerase II inhibitor, RPA modulator.

    ≥98%
  • A5281

    Angiotensin II (4-8), human

    Endogenous peptide fragment, involved in vasoco...

    ≥95%
  • A4806

    Ambroxol Hydrochloride

    Expectorant.

    ≥98%
  • G1408

    GDC-0449

    Smo inhibitor.

    ≥98%
  • A081014

    Acalabrutinib

    Inhibitor of Bruton’s tyrosine kinase (BTK).<...

    ≥99%
  • R5602

    Ro 20-1724

    Phosphodiesterase inhibitor that produces anti-...

    ≥98%
  • G3460

    Ginsenoside F1

    Triterpene saponin found in species of Panax.

    ≥98%