MLN8237

Name: MLN8237
SKU: M4652
Availability: InStock

Product ID M4652

Cas No. 1028486-01-2

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

MLN8237 inhibits aurora kinase A (AurA) preventing mitotic spindle formation and proper completion of mitosis. MLN8237 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for multiple myeloma, non-Hodgkin’s lymphoma, and chronic lymphocytic leukemia (CLL). In bladder cancer cells, MLN8237 induces cell cycle arrest, aneuploidy, and apoptosis; in animal models of bladder cancer, this compound inhibits tumor growth. Additionally, MLN8237 inhibits tumor growth of neuroblastomas in vivo as well. In HUVECs, MLN8237 decreases tubule formation and inhibits VEGF secretion, suggesting potential anti-angiogenic activity.

Product Info

Cas No.	1028486-01-2
Purity	≥98%
Formula	C₂₇H₂₀ClFN₄O₄
Formula Wt.	518.92
IUPAC Name	4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid
Synonym	Alisertib
Solubility	DMSO 27 mg/mL (52.03 mM) Water Insoluble Ethanol Insoluble
Appearance	Pale Yellow Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	M4652 MSDS PDF
Info Sheet	M4652 Info Sheet PDF

References

Romain C, Paul P, Kim KW, et al. Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. J Pediatr Surg. 2014 Jan;49(1):159-65. PMID: 24439602.

Kelly KR, Shea TC, Goy A, et al. Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia. Invest New Drugs. 2013 Dec 20. [Epub ahead of print]. PMID: 24352795.

Zhou N, Singh K, Mir MC, et al. The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo. Clin Cancer Res. 2013 Apr 1;19(7):1717-28. PMID: 23403633.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

MLN8237

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Chloroquine Diphosphate

Ramelteon

S-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine

Pluripotin

Naphazoline Hydrochloride

Glucagon-like Peptide II, human

H89

Thymosin α-1 Acetate

GSK-461364

Cinacalcet Hydrochloride

Clarithromycin

Chondroitin Sulfate, chicken

3-Methyladenine

Epigallocatechin Gallate

OTX-015

Ketoconazole

Betulin-3-Acetate

Nordihydroguaiaretic Acid

Tebipenem

δ-Tocotrienol

Footer