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Molsidomine

Molsidomine

Product ID M5746
Cas No. 25717-80-0
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $60.10 In stock
1 g $97.70 In stock
5 g $375.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Molsidomine is a NO donor that exhibits vasodilatory, cardioprotective, anti-atherosclerotic, and anticoagulant activities. Molsidomine inhibits PDGF-induced smooth muscle cell migration and proliferation and suppresses carotid artery neointima formation in vivo by inhibiting activity of annexin A2. In vitro, molsidomine inhibits activated platelet adhesion.

Product Info

Cas No.

25717-80-0

Purity

≥98%

Formula

C9H14N4O4

Formula Wt.

242.23

Chemical Name

N-(Ethoxycarbonyl)-3-(4-morpholinyl)sydnone imine

IUPAC Name

(1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate

Synonym

Corvaton, Corvasal, Molsidolat, Morial, Motazominn

Melting Point

140-141°C

Solubility

Soluble in chloroform, methanol (50 mg/mL), ethanol (35 mg/mL), DMSO (70 mg/mL), DMF (13 mg/mL), ethyl acetate. Slightly soluble in water, acetone or benzene.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M5746 MSDS PDF

Info Sheet

M5746 Info Sheet PDF

References

Harnek J, Zoucas E, de Sá VP, et al. Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway. BMC Cardiovasc Disord. 2011 Jun 11;11:30. PMID: 21663688.

Won KJ, Lee P, Jung SH, et al. 3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration. Proteomics. 2011 Jan;11(2):193-201. PMID: 21204247.

Cardoso MH, Morganti RP, Lilla S, et al. The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion. Eur J Pharmacol. 2010 Feb 10;627(1-3):229-34. PMID: 19895807.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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  • This field is for validation purposes and should be left unchanged.

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