• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
N-(4-Hydroxyphenyl)retinamide

N-(4-Hydroxyphenyl)retinamide

Product ID H9613
Cas No. 65646-68-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $183.60 In stock
10 mg $337.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fenretinide is a synthetic retinol/vitamin A analog that binds RBP4 and exhibits anti-diabetic, antihypertensive, an anticancer chemotherapeutic activities. Fenretinide increases ceramide levels in vivo. In obese mice, fenretinide increases fat oxidation and decreases levels of total cholesterol and triglycerides, preventing fatty liver disease. Fenretinide also inhibits Des1, improving insulin sensitivity and normalizing glucose homeostasis in other animal models. Additionally, this compound induces caspase 3-dependent apoptosis in cancer cells and decrease tumor volume in animal models of lung cancer.

Product Info

Cas No.

65646-68-6

Purity

≥98%

Formula

C26H33NO2

Formula Wt.

391.55

IUPAC Name

(2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6, 6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide

Synonym

Fenretinide, 4-HPR, Retinoic acid p-hydroxyanilide

Melting Point

173-175°C

Solubility

Soluble in DMSO (25mg/mL) or ethanol (25mg/mL).

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H9613 MSDS PDF

Info Sheet

H9613 Info Sheet PDF

References

Durante S, Orienti I, Teti G, et al. Anti-tumor activity of fenretinide complexed with human serum albumin in lung cancer xenograft mouse model. Oncotarget. 2014 May 28. [Epub ahead of print]. PMID: 25015569.

Bikman BT, Guan Y, Shui G, et al. Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J Biol Chem. 2012 May 18;287(21):17426-37. PMID: 22474281.

Koh IU, Jun HS, Choi JS, et al. Fenretinide ameliorates insulin resistance and fatty liver in obese mice. Biol Pharm Bull. 2012;35(3):369-75. PMID: 22382323.

Guilbault C, De Sanctis JB, Wojewodka G, et al. Fenretinide corrects newly found ceramide deficiency in cystic fibrosis. Am J Respir Cell Mol Biol. 2008 Jan;38(1):47-56. PMID: 17656682.

Wu JM, DiPietrantonio AM, Hsieh TC. Mechanism of fenretinide (4-HPR)-induced cell death. Apoptosis. 2001 Oct;6(5):377-88. PMID: 11483862.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A7203

    AS-703026

    MEK1/2 inhibitor.

    ≥98%
  • P6859

    Proctolin

    Neuropeptide found in crustaceans and insects.<...

    ≥95%
  • T7860

    TTP 22

    Casein kinase 2 inhibitor.

    ≥98%
  • T3132

    Thiazovivin

    ROCK inhibitor.

    ≥98%
  • M4452

    MLN2480

    Raf inhibitor.

    ≥98%
  • C0378

    Catharanthine Tartrate

    Alkaloid found in Catharanthus, precursor in sy...

    ≥97%
  • N1984

    Neuropeptide FF

    Endogenous RF-amide peptide, involved in nocice...

    ≥95%
  • A0968

    Adrenocorticotropic Hormone (1-24), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • M0126

    Magainin 2

    Antimicrobial peptide found in frogs, induces p...

    ≥95%
  • I7155

    Isoindigo

    Potential AhR binding agent.

    ≥98%
  • B3573

    Bisdemethoxycurcumin

    Curcumin derivative; DNMT1 and α-amylase inhib...

    ≥98%
  • M5793

    Moxifloxacin Free Base

    Fluoroquinolone; topoisomerase IV, topoisomeras...

    ≥98%
  • D3320

    Difenoconazole

    Triazole; 14-α demethylase inhibitor, potentia...

    ≥98%
  • P1635

    Peiminine

    Steroidal alkaloid found in Fritillaria; M2 mAC...

    ≥98%
  • S1810

    Secnidazole

    Nitroimidazole, binds DNA; nucleic acid synthes...

    ≥98%
  • R5773

    Rosiglitazone

    Thiazolidinedione; PPARγ agonist.

    ≥99%
  • D1628

    5,6-Dehydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • S8014

    Substance P, Free Acid

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • A2500

    AG-1478

    EGFR inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only