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N-Acetyl-S-(N′-phenethylthiocarbamoyl)-L-cysteine

Product ID A0920
Cas No. 131918-97-3
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $102.10 In stock
25 mg $171.60 In stock
100 mg $515.20 In stock
500 mg $1,785.70 In stock
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  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

This compound is an N-acetyl cysteine conjugate of phenethylisothiocyanate (PEITC-NAC), exhibiting anticancer chemotherapeutic and chemopreventive activities. In lung cancer and prostate cancer models, PEITC-NAC increases activation of JNK, p53, and MAPKs, inducing apoptosis, decreasing tumor growth, and limiting tumorigenesis.

Product Info

Cas No.

131918-97-3

Purity

≥95%

Formula

C14H18N2O3S2

Formula Wt.

326.43

Chemical Name

Phenethyl isothiocyanate N-acetyl-L-cysteine conjugate; PEITC N-acetyl-L-cysteine conjugate

IUPAC Name

(2R)-2-acetamido-3-(2-phenylethylcarbamothioylsulfanyl)propanoic acid

Synonym

PEITC-NAC

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A0920 MSDS PDF

Info Sheet

A0920 Info Sheet PDF

References

Kassie F, Melkamu T, Endalew A, et al. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. Carcinogenesis. 2010 Sep;31(9):1634-41. PMID: 20603442.

Yang YM, Conaway CC, Chiao JW, et al. Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. Cancer Res. 2002 Jan 1;62(1):2-7. PMID: 11782348.

Chiao JW, Chung F, Krzeminski J, et al. Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate. Int J Oncol. 2000 Jun;16(6):1215-9. PMID: 10811998.

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