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N-fMLF is a peptide that binds n-formyl peptide receptors (FPRs) on neutrophils, playing a role in neutrophil activation. This peptide activates NADPH oxidase-dependent respiratory burst in neutrophils, generating ROS and inflammatory signaling cascades.
| Cas No. | 59880-97-6 |
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| Purity | ≥95% |
| Formula | C21H31N3O5S |
| Formula Wt. | 437.6 |
| IUPAC Name | 2-[[2-[(2-formamido-4-methylsulfanylbutanoyl)amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid |
| Synonym | N-Formylmethionine leucyl-phenylalanine; L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-; Tyramine HCl; N-Formyl-Met-Leu-Phe; Chemotactic peptide. |
| Solubility | Soluble in acetic acid (20 mg/mL), ethanol (2 mg/mL), DMSO (4 mg/mL), DMF (50 mg/mL). |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Hurtado-Nedelec M, Makni-Maalej K, Gougerot-Pocidalo MA, et al. Assessment of priming of the human neutrophil respiratory burst. Methods Mol Biol. 2014;1124:405-12. PMID: 24504964.
Andréasson E, Önnheim K, Forsman H. The subcellular localization of the receptor for platelet-activating factor in neutrophils affects signaling and activation characteristics. Clin Dev Immunol. 2013;2013:456407. PMID: 24069041.
Sengeløv H, Boulay F, Kjeldsen L, et al. Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils. Biochem J. 1994 Apr 15;299 ( Pt 2):473-9. PMID: 8172608.