• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nefazodone Hydrochloride

Nefazodone Hydrochloride

Product ID N1822
Cas No. 82752-99-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $97.10 In stock
5 g $416.90 In stock
25 g $1,327.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nefazodone is an atypical antidepressant that inhibits 5-HT2 receptors, serotonin transporters (SERT), norepinephrine transporters (NET), and human ether-a-go-go-related (hERG) K+ channels. Nefazodone decreases immobility time in the forced swim test and is clinically used to treat depression, panic disorder, and post-traumatic stress disorder (PTSD).

Product Info

Cas No.

82752-99-6

Purity

≥98%

Formula

C25H32ClN5O2 • HCl

Formula Wt.

506.48

Chemical Name

2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5- ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride

IUPAC Name

2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2- phenoxyethyl)-1,2,4-triazol-3-one;hydrochloride

Synonym

BMY-13754, MJ-13754-1, Dutonin, Serzone

Melting Point

186-187°C

Solubility

Slightly soluble in water.

Appearance

A White to off-White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N1822 MSDS PDF

Info Sheet

N1822 Info Sheet PDF

References

Shin DS, Park MJ, Lee HA, et al. A novel assessment of nefazodone-induced hERG inhibition by electrophysiological and stereochemical method. Toxicol Appl Pharmacol. 2014 Feb 1;274(3):361-71. PMID: 24374264.

Clayton AH, Montejo AL. Major depressive disorder, antidepressants, and sexual dysfunction. J Clin Psychiatry. 2006;67 Suppl 6:33-7. PMID: 16848675.

Dremencov E, Gispan-Herman I, Rosenstein M, et al. The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):141-7. PMID: 14687868.

Eckler JR, Rabin RA, Winter JC. Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control. Pharmacol Biochem Behav. 2003 May;75(2):405-10. PMID: 12873632.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S8007

    Substance P (1-7)

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • G4532

    Gliclazide

    Sulfonylurea; SUR1 antagonist.

    ≥98%
  • M2409

    MGCD-0103

    HDAC inhibitor.

    ≥98%
  • R5602

    Ro 20-1724

    Phosphodiesterase inhibitor that produces anti-...

    ≥98%
  • B9700

    BYL719

    p110α PI3K inhibitor.

    ≥99%, ≥99%ee
  • G0096

    GAY

    Tripeptide, used to tag proteins.

    ≥95%
  • P200637

    PF-04745637

    TRPA1 antagonist

    ≥98%
  • A822686

    Aureothricin

    Aureothricin is a member of the dithiolopyrrolo...

    ≥98%
  • A0101

    4-bromo-A23187

    Non-fluorescent halogenated A23187 analog, Ca2+...

    ≥98%
  • A5276

    Angiotensin I, human

    Endogenous peptide, cleavage product of angiote...

    ≥98%
  • L960012

    LY-3214996

    ERK1/2 inhibitor.

    ≥98%
  • L3326

    Ligustrazine Hydrochloride

    Dihydropyrazine found in Ligusticum walliichi. ...

    ≥98%
  • A3080

    AHU-377 Tris Salt

    LBQ657 prodrug; neprilysin inhibitor.

    ≥99%
  • R3222

    Rifamycin SV Monosodium

    Ansamycin; bacterial DNA-dependent RNA polymera...

    ≥98%
  • I9060

    IWP-2

    PORCN inhibitor.

    ≥98%
  • B5609

    Boc-GRR-AMC

    Peptide, protease substrate.

    ≥98%
  • F5968

    Foretinib

    ROS1, MET, Ron, Axl, TIE-2, VEGFR2 inhibitor.

    ≥98%
  • A0102

    A23187 Ca-Mg

    Ca2+ ionophore.

    ≥98%, TLC
  • S6800

    SR1001

    RORα/γ inverse agonist.

    ≥99%
  • A4805

    Amastatin Hydrochloride Hydrate

    Aminopeptidase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only