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Neostigmine is a reversible inhibitor of acetylcholine esterase (AChE) that acts peripherally only. Neostigmine is clinically used to reverse the effects of neuromuscular junction (NMJ) blockers and to treat muscular symptoms of myasthenia gravis. Neostigmine induces muscular contractions in muscle tissue and improves overall muscle tone.
| Cas No. | 114-80-7 |
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| Purity | ≥92% |
| Formula | C12H19BrN2O2 |
| Formula Wt. | 303.20 |
| Chemical Name | 3-(N,N-Dimethylcarbamoyloxy)-N,N,N-trimethyl- anilinium bromide |
| IUPAC Name | [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide |
| Synonym | Prostigmine |
| Melting Point | 175-177°C |
| Solubility | Soluble in water or ethanol. |
| Appearance | White Crystal Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Dahaba AA, Bornemann H, Hopfgartner E, et al. Effect of sugammadex or neostigmine neuromuscular block reversal on bispectral index monitoring of propofol/remifentanil anaesthesia. Br J Anaesth. 2012 Apr;108(4):602-6. PMID: 22315331.
Cellini J, Zaura Jukic AM, LePard KJ. Neostigmine-induced contraction and nitric oxide-induced relaxation of isolated ileum from STZ diabetic guinea pigs. Auton Neurosci. 2011 Dec 7;165(2):178-90. PMID: 21880552.