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Neurokinin A (4-10)

Neurokinin A (4-10)

Product ID N1977
Cas No. 97559-35-8
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $68.30 In stock
2 mg $89.30 In stock
5 mg $157.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Neurokinin A is an endogenous neuromodulatory peptide formerly known as substance K. Like other neurokinins, neurokinin A induces contraction in ileal smooth muscle cells and contributes to nociceptive activity. Neurokinin A exhibits pro-inflammatory, bronchoconstrictive, and vasodilatory activities. In macrophages, neurokinin A binds neurokinin 1/2 (NK1/2) receptors, activating ERK1/2, PI3K/Akt, and NF-κB increasing expression of inflammatory cytokines. Neurokinin A also promotes vasodilation, decreases heart rate, and induces bronchoconstriction in animal models.

Product Info

Cas No.

97559-35-8

Purity

≥95%

Formula

C34H54N8O10S

Formula Wt.

766.92

IUPAC Name

(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid

Synonym

Substance K

Solubility

Soluble in water, DMSO.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N1977 MSDS PDF

Info Sheet

N1977 Info Sheet PDF

References

Sun J, Ramnath RD, Tamizhselvi R, et al. Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways. Am J Physiol Cell Physiol. 2008 Sep;295(3):C679-91. PMID: 18596216.

Fusco M, D'Andrea G, Miccichè F, et al. Neurogenic inflammation in primary headaches. Neurol Sci. 2003 May;24 Suppl 2:S61-4. PMID: 12811594.

Suzuki N, Mizuno K, Gomi Y. Tachykinin-induced contractions in the circular muscle of guinea pig ileum. Jpn J Pharmacol. 1994 Jul;65(3):233-40. PMID: 7528285.

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