• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Neuropeptide FF

Neuropeptide FF

Product ID N1984
Cas No. 99566-27-5
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $225.80 In stock
10 mg $393.80 In stock
25 mg $787.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Neuropeptide FF is an endogenous RF amide family peptide that exhibits anti-inflammatory and anti-analgesic activities. Neuropeptide FF binds NPFF1/2 receptors in the brain, regulating blood pressure and hormone secretion. In LPS-stimulated macrophages, neuropeptide FF decreases NO production and inhibits NF-κB translocation; in animal models, it suppresses carrageenan-induced edema. Additionally, neuropeptide FF inhibits opioid-induced stress-mediated analgesia in the forced swim test, displaying anti-opioid activity.

Product Info

Cas No.

99566-27-5

Purity

≥95%

Formula

C54H76N14O10

Formula Wt.

1081.3

IUPAC Name

(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[(2-amino-3- phenylpropanoyl)amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino] -5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[(1-amino-1-oxo- 3-phenylpropan-2-yl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl] pentanediamide

Synonym

NPFF, Octapeptide F8FA, F-8-F-NH2, Neuro FF Morphine Modulating Neuro F-8-F-NH2.

Solubility

Soluble in water (0.5 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N1984 MSDS PDF

Info Sheet

N1984 Info Sheet PDF

References

Sun YL, Zhang XY, Sun T, et al. The anti-inflammatory potential of neuropeptide FF in vitro and in vivo. Peptides. 2013 Sep;47:124-32. PMID: 23856454.

Jhamandas JH, Goncharuk V. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013 Feb 7;4:8. PMID: 23404625.

Li N, Han ZL, Fang Q, et al. Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behav Brain Res. 2012 Aug 1;233(2):428-33. PMID: 22659392.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L9602

    LY-2874455

    FGFR inhibitor.

    ≥98%
  • P7359

    Psoralidin

    Phenol found in Psoralea coryfolia.

    ≥98%
  • C0016

    Caerulomycin A

    Bipyridamine toxin.

    ≥96%
  • K6276

    (E)-KPT-330

    CRM1-selective inhibitor of nuclear export.

    ≥99%
  • C4510

    Climbazole

    14-α demethylase inhibitor.

    ≥99%
  • D5746

    Dolasetron

    5-HT3 antagonist.

    ≥98%
  • N344786

    N-Nitroso Valsartan Methyl Ester

    Valsartan impurity

  • R2516

    RGES

    Peptide, used as control to measure RGDS peptid...

    ≥95%
  • P3440

    PIK-293

    p110δ PI3K inhibitor.

    ≥98%
  • R580665

    Roquefortine C

    Mycotoxin produced by various fungi including t...

    ≥98%
  • A2500

    AG-1478

    EGFR inhibitor.

    ≥98%
  • G4479

    Glucagon (19-29), human

    Endogenous peptide hormone, glugagon fragment; ...

    ≥95%
  • G1210

    GDC-0623

    MEK inhibitor.

    ≥98%
  • T0108

    10-Deacetyl-7-xylosyltaxol

    Taxane found in species of Taxus; potential mic...

    ≥98%
  • I5213

    Indole-3-carbinol

    Indole, glucosinolate found in cruciferous vege...

    ≥98%
  • T7133

    Trimetazidine Dihydrochloride

    Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...

    ≥99%
  • P3209

    Piceatannol

    Polyphenolic hydroxystilbene, resveratrol deri...

    ≥99%
  • T0109

    13-Acetyl-9-dihydrobaccatin-III

    Found in Taxus, starting material for synthesis...

    ≥98%
  • I5313

    Indinavir Sulfate

    HIV protease, GLUT4, calpain inhibitor.

    ≥99%
  • I1400

    Idarubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only