LKT Labs

Biochemicals for Life Science Research

Neuropeptide FF

Neuropeptide FF

Product ID N1984
Cas No. 99566-27-5
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $225.80 In stock
10 mg $393.80 In stock
25 mg $787.50 In stock
Bulk Quote

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Description

Neuropeptide FF is an endogenous RF amide family peptide that exhibits anti-inflammatory and anti-analgesic activities. Neuropeptide FF binds NPFF1/2 receptors in the brain, regulating blood pressure and hormone secretion. In LPS-stimulated macrophages, neuropeptide FF decreases NO production and inhibits NF-κB translocation; in animal models, it suppresses carrageenan-induced edema. Additionally, neuropeptide FF inhibits opioid-induced stress-mediated analgesia in the forced swim test, displaying anti-opioid activity.

Product Info

Cas No.

99566-27-5
Purity

≥95%
Formula

C54H76N14O10
Formula Wt.

1081.3
IUPAC Name

(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[(2-amino-3- phenylpropanoyl)amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino] -5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[(1-amino-1-oxo- 3-phenylpropan-2-yl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl] pentanediamide
Synonym

NPFF, Octapeptide F8FA, F-8-F-NH2, Neuro FF Morphine Modulating Neuro F-8-F-NH2.
Solubility

Soluble in water (0.5 mg/mL).
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N1984 MSDS PDF
Info Sheet

N1984 Info Sheet PDF

References

Sun YL, Zhang XY, Sun T, et al. The anti-inflammatory potential of neuropeptide FF in vitro and in vivo. Peptides. 2013 Sep;47:124-32. PMID: 23856454.

Jhamandas JH, Goncharuk V. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013 Feb 7;4:8. PMID: 23404625.

Li N, Han ZL, Fang Q, et al. Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behav Brain Res. 2012 Aug 1;233(2):428-33. PMID: 22659392.

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