LKT Labs

Biochemicals for Life Science Research

Neuropeptide FF

Neuropeptide FF

Product ID N1984
Cas No. 99566-27-5
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $225.80 In stock
10 mg $393.80 In stock
25 mg $787.50 In stock
Bulk Quote

Quicklinks

Description

Neuropeptide FF is an endogenous RF amide family peptide that exhibits anti-inflammatory and anti-analgesic activities. Neuropeptide FF binds NPFF1/2 receptors in the brain, regulating blood pressure and hormone secretion. In LPS-stimulated macrophages, neuropeptide FF decreases NO production and inhibits NF-κB translocation; in animal models, it suppresses carrageenan-induced edema. Additionally, neuropeptide FF inhibits opioid-induced stress-mediated analgesia in the forced swim test, displaying anti-opioid activity.

Product Info

Cas No.

99566-27-5
Purity

≥95%
Formula

C54H76N14O10
Formula Wt.

1081.3
IUPAC Name

(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[(2-amino-3- phenylpropanoyl)amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino] -5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[(1-amino-1-oxo- 3-phenylpropan-2-yl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl] pentanediamide
Synonym

NPFF, Octapeptide F8FA, F-8-F-NH2, Neuro FF Morphine Modulating Neuro F-8-F-NH2.
Solubility

Soluble in water (0.5 mg/mL).
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N1984 MSDS PDF
Info Sheet

N1984 Info Sheet PDF

References

Sun YL, Zhang XY, Sun T, et al. The anti-inflammatory potential of neuropeptide FF in vitro and in vivo. Peptides. 2013 Sep;47:124-32. PMID: 23856454.

Jhamandas JH, Goncharuk V. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013 Feb 7;4:8. PMID: 23404625.

Li N, Han ZL, Fang Q, et al. Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behav Brain Res. 2012 Aug 1;233(2):428-33. PMID: 22659392.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G1745

    Gemcitabine Hydrochloride

    Nucleoside (deoxycytidine) analog; ribonucleoti...

    ≥98%
  • K977545

    Kynurenic acid

    Endogenous NMDA receptor antagonist.

    ≥99%
  • T0299

    Tazobactam Sodium

    β-lactamase inhibitor.

    ≥98%
  • T1853

    Tenovin-6

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • A0921

    N-Acetyl-D-Leucine

    D-amino acid, incorporated into bacterial cell ...

    ≥98%
  • K0552

    Kb NB 77-78

    CID-797718 analog; potential PKD1 binding agent...

    ≥98%
  • V3277

    Vitamin E

    Synthetic vitamin E, antioxidant.

    ≥98%
  • A4646

    ALLN

    Calpain I/II inhibitor.

    ≥98%
  • F1654

    Fenoldopam Mesylate

    Benzazepine derivative; D1 partial agonist, pot...

    ≥98%
  • C0160

    Canrenone

    Metabolite of spironolactone; Na+/K+ ATPase par...

    ≥98%
  • P0008

    Pituitary Adenylate Cyclase-activating Peptide (6-38), human/sheep/rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • T2935

    Thiamphenicol

    Chloramphenicol derivative; protein translation...

    ≥98%
  • I7259

    Isoproterenol Hydrochloride

    β-adrenergic agonist.

    ≥98%
  • M4100

    MK-0524

    DP1 antagonist.

    ≥99%
  • E544766

    Enterocin

    A bacteriocin

    ≥95%
  • T8004

    Tubeimoside I

    Triterpene saponin originally found in Bolboste...

    ≥96%
  • P698574

    Prolylrapamycin

    Rapamycin analog
  • P4008

    PKC412

    Staurosporine derivative; PKC and FLT3 inhibito...

    ≥98%
  • E2003

    Efavirenz

    Non-nucleoside RT inhibitor.

    ≥99%
  • E4417

    Eledoisin Related Peptide

    Peptide, substance P analog; NK agonist.

    ≥95%