Norfloxacin

Name: Norfloxacin
SKU: N5768
Availability: InStock

Product ID N5768

Cas No. 70458-96-7

Purity ≥98%

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Description

Norfloxacin is a first generation fluoroquinolone antibiotic that exhibits antibacterial, anti-inflammatory, and anticancer activities. Norfloxacin inhibits DNA gyrase and topoisomerase IV; it is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Product Info

Cas No.	70458-96-7
Purity	≥98%
Formula	C₁₆H₁₈FN₃O₃
Formula Wt.	319.33
Chemical Name	1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
IUPAC Name	1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
Synonym	Baccidal, Sebercim
Melting Point	227-228°C
Solubility	Soluble in water (0.28 mg/mL), methanol (1 mg/mL), ethanol (1.9 mg/mL).
Appearance	Yellowish white crystal powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	N5768 MSDS PDF
Info Sheet	N5768 Info Sheet PDF

References

Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.

Gómez-Hurtado I, Zapater P, Bellot P, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis. Hepatology. 2011 Mar;53(3):935-44. PMID: 21374664.

Padeĭskaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48(9):28-36. PMID: 15002177.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

Ho YB, Zakaria MP, Latif PA, Saari N. Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia. Sci Total Environ. 2014 Aug 1;488-489:261-267. PMID: 24836135.

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Norfloxacin

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