Description
Nystatin is a polyene macrolide antibiotic initially produced by Streptomyces. Nystatin exhibits antifungal activity, binding ergosterol and forming pores in fungal membranes.
Nystatin
Product ID N9874
Cas No. 1400-61-9
Purity 4400u/mg
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 1400-61-9 |
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| Purity | 4400u/mg |
| Formula | C47H75NO17 |
| Formula Wt. | 926.09 |
| IUPAC Name | (4E,6E,8E,10E,14E,16E,18S,19R,20R,21S,35S)-3-[(2S,3S,4S,5S, 6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,29,32,33,35, 37-octahydroxy-18,20,21-trimethyl-23-oxo-22, 39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14, 16-hexaene-38-carboxylic acid |
| Synonym | Fungicidin, Candex, Mycostatin, Nystan, O-V Statin |
| Melting Point | 160°C (dec) |
| Solubility | Slightly soluble in methanol (<0.5 mg/mL), ethanol and water. |
| Appearance | Pale Yellow Powder |
Shipping and Storage
| Store Temp | 4°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Serhan G, Stack CM, Perrone GG, et al. The polyene antifungals, amphotericin B and nystatin, cause cell death in Saccharomyces cerevisiae by a distinct mechanism to amphibian-derived antimicrobial peptides. Ann Clin Microbiol Antimicrob. 2014 May 12;13:18. PMID: 24884795.
Fjaervik E, Zotchev SB. Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei. Appl Microbiol Biotechnol. 2005 Jun;67(4):436-43. PMID: 15700127.
Hammond SM. Biological activity of polyene antibiotics. Prog Med Chem. 1977;14:105-79. PMID: 345355.