LKT Labs

Biochemicals for Life Science Research

Obatoclax

Product ID O0400
Cas No. 803712-67-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $109.30 In stock
25 mg $401.80 In stock
50 mg $610.70 In stock
Bulk Quote

Quicklinks

Description

Obatoclax is a BH3 mimetic and inhibitor of Bcl-2 and Bcl-xl that displays anti-metastatic and anticancer chemotherapeutic activities; it is currently in clinical trials as a potential treatment for various cancers. Obatoclax induces autophagy and apoptosis in adenoid cystic carcinoma cells and decreases tumor formation and growth in animal models of hepatoblastoma. In cellular models of colorectal cancer, obatoclax inhibits cell growth, induces G1 phase cell cycle arrest, and suppresses proliferation, migration, and invasion.

Product Info

Cas No.

803712-67-6
Purity

≥98%
Formula

C20H19N3O
Formula Wt.

317.38
IUPAC Name

2-{(2Z)-2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl}-1H-indole
Synonym

GX15-070
Solubility

DMSO 83 mg/mL (200.73 mM) Water Insoluble Ethanol Insoluble
Appearance

Darkish green powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

O0400 MSDS PDF
Info Sheet

O0400 Info Sheet PDF

References

Liang LZ, Ma B, Liang YJ, et al. Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells. Oral Dis. 2014 Dec 8. [Epub ahead of print]. PMID: 25482163.

Arellano ML, Borthakur G, Berger M, et al. A phase II, multicenter, open-label study of obatoclax mesylate in patients with previously untreated myelodysplastic syndromes with anemia or thrombocytopenia. Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):534-9. PMID: 25052051.

Koehler BC, Scherr AL, Lorenz S, et al. Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. PLoS One. 2014 Sep 5;9(9):e106571. PMID: 25192188.

Lieber J, Ellerkamp V, Vogt F, et al. BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma. Exp Cell Res. 2014 Mar 10;322(1):217-25. PMID: 24355809.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C2951

    Chlortetracycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥85%
  • S8046

    R-Sulforaphane, High Purity

    Naturally occuring isothiocyanate found in broc...

    ≥98%
  • S1061

    Small Cardioactive Peptide B

    Peptide found in molluscs, cardiomodulator.

    ≥95%
  • E6356

    Epothilone D

    Microtubule depolymerization inhibitor.

    ≥98%
  • C5972

    Corynoline

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • P7358

    Psoralen

    Furanocoumarin found in Psoralea coryfolia, DNA...

    ≥98%
  • T3305

    Tibolone

    Synthetic steroid hormone used in HRT; SERM, PR...

    ≥98%
  • A9817

    Azelaic Acid

    Dicarboxylic acid found in Arabidopsis; PPARγ ...

    ≥98%
  • N176498

    Nemorosone

    Found in the propolis of honey bees.

    ≥99%
  • N4972

    NMS-873

    Valosin-containing protein inhibitor.

    ≥98%
  • C2965

    Chromium Picolinate

    Used to prevent chromium deficiency and to decr...

    ≥98%
  • S7868

    SRT1720 Hydrochloride

    SIRT 1 activator, SIRT3 inhibitor.

    ≥98%
  • C281006

    Chaetocin

    Chaetocin is naturally produced by Chaetomium s...

    ≥98%
  • C0221

    Caffeine

    Xanthine alkaloid found in coffee, tea, and oth...

    ≥98%
  • M0273

    Mastoparan 8

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • I6933

    Irinotecan Hydrochloride Trihydrate

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • B1668

    Berteroin

    Thio sulforaphane analog, ITC.

    ≥97%
  • K0038

    Kahweol Oleate

    Diterpene found in coffee beans.

    ≥98%
  • M9368

    Myristicin

    Allylbenzene found in spices and umbelliferous ...

    ≥98%
  • O9302

    Oxacillin Sodium Monohydrate

    β-lactam; penicillin binding protein inhibitor...

    ≥98%