LKT Labs

Biochemicals for Life Science Research

Obatoclax

Obatoclax

Product ID O0400
Cas No. 803712-67-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $115.00 In stock
25 mg $422.00 In stock
50 mg $641.00 In stock
Bulk Quote

Quicklinks

Description

Obatoclax is a BH3 mimetic and inhibitor of Bcl-2 and Bcl-xl that displays anti-metastatic and anticancer chemotherapeutic activities; it is currently in clinical trials as a potential treatment for various cancers. Obatoclax induces autophagy and apoptosis in adenoid cystic carcinoma cells and decreases tumor formation and growth in animal models of hepatoblastoma. In cellular models of colorectal cancer, obatoclax inhibits cell growth, induces G1 phase cell cycle arrest, and suppresses proliferation, migration, and invasion.

Product Info

Cas No.

803712-67-6
Purity

≥98%
Formula

C20H19N3O
Formula Wt.

317.38
IUPAC Name

2-{(2Z)-2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl}-1H-indole
Synonym

GX15-070
Solubility

DMSO 83 mg/mL (200.73 mM) Water Insoluble Ethanol Insoluble
Appearance

Darkish green powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

O0400 MSDS PDF
Info Sheet

O0400 Info Sheet PDF

References

Liang LZ, Ma B, Liang YJ, et al. Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells. Oral Dis. 2014 Dec 8. [Epub ahead of print]. PMID: 25482163.

Arellano ML, Borthakur G, Berger M, et al. A phase II, multicenter, open-label study of obatoclax mesylate in patients with previously untreated myelodysplastic syndromes with anemia or thrombocytopenia. Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):534-9. PMID: 25052051.

Koehler BC, Scherr AL, Lorenz S, et al. Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. PLoS One. 2014 Sep 5;9(9):e106571. PMID: 25192188.

Lieber J, Ellerkamp V, Vogt F, et al. BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma. Exp Cell Res. 2014 Mar 10;322(1):217-25. PMID: 24355809.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H1657

    Heparin-binding Peptide

    Peptide, binds heparin.

    ≥95%
  • D5897

    Doxycycline Hyclate

    Tetracycline; protein translation inhibitor, MM...

    ≥97%
  • A1592

    ADX-47273

    mGluR5 positive modulator.

    ≥98%
  • I6068

    Ipriflavone

    Synthetic isoflavone.

    ≥98%
  • M7530

    [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone

    Semi-synthetic peptide, melanocortin analog; MC...

    ≥98%
  • N859614

    NVP-LDE225

    Smo inhibitor.

    ≥98%
  • A9814

    AZD-4547

    FGFR inhibitor.

    ≥98%
  • Z161024

    α-Zearalenol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • A5327

    Anagrelide

    Imidazoquinazoline; PDE3 inhibitor.

    ≥98%
  • A0025

    17-Allylaminogeldanamycin

    Geldanamycin derivative; HSP90 inhibitor.

    ≥97%
  • D5747

    Dolasetron Mesylate Hydrate

    5-HT3 antagonist.

    ≥98%
  • B1978

    Betulin-3-Acetate

    Pentacyclic triterpene found in various plant s...

    ≥97%
  • C2956

    Cholecalciferol

    Endogenous vitamin D prodrug.

    ≥98%
  • P2100

    PF-06447475

    LRRK2 inhibitor.

    ≥98%
  • A6269

    Apremilast

    PDE4 inhibitor.

    ≥98%
  • P0146

    Palmitoyl-L-carnitine

    Long chain acylcarnitine involved in fatty acid...

    ≥98%
  • A7202

    AS-604850

    p110γ PI3K inhibitor.

    ≥98%
  • S8245

    Sulfadiazine

    Sulfonamide; folate production inhibitor.

    ≥98%
  • C0265

    Carnosic Acid

    Diterpene found in Rosmarinus.

    ≥98%
  • C0151

    α-Calcitonin Gene Related Peptide, human

    Endogenous calcitonin-family peptide, involved ...

    ≥95%