LKT Labs

Biochemicals for Life Science Research

Obatoclax

Obatoclax

Product ID O0400
Cas No. 803712-67-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $115.00 In stock
25 mg $422.00 In stock
50 mg $641.00 In stock
Bulk Quote

Quicklinks

Description

Obatoclax is a BH3 mimetic and inhibitor of Bcl-2 and Bcl-xl that displays anti-metastatic and anticancer chemotherapeutic activities; it is currently in clinical trials as a potential treatment for various cancers. Obatoclax induces autophagy and apoptosis in adenoid cystic carcinoma cells and decreases tumor formation and growth in animal models of hepatoblastoma. In cellular models of colorectal cancer, obatoclax inhibits cell growth, induces G1 phase cell cycle arrest, and suppresses proliferation, migration, and invasion.

Product Info

Cas No.

803712-67-6
Purity

≥98%
Formula

C20H19N3O
Formula Wt.

317.38
IUPAC Name

2-{(2Z)-2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl}-1H-indole
Synonym

GX15-070
Solubility

DMSO 83 mg/mL (200.73 mM) Water Insoluble Ethanol Insoluble
Appearance

Darkish green powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

O0400 MSDS PDF
Info Sheet

O0400 Info Sheet PDF

References

Liang LZ, Ma B, Liang YJ, et al. Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells. Oral Dis. 2014 Dec 8. [Epub ahead of print]. PMID: 25482163.

Arellano ML, Borthakur G, Berger M, et al. A phase II, multicenter, open-label study of obatoclax mesylate in patients with previously untreated myelodysplastic syndromes with anemia or thrombocytopenia. Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):534-9. PMID: 25052051.

Koehler BC, Scherr AL, Lorenz S, et al. Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. PLoS One. 2014 Sep 5;9(9):e106571. PMID: 25192188.

Lieber J, Ellerkamp V, Vogt F, et al. BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma. Exp Cell Res. 2014 Mar 10;322(1):217-25. PMID: 24355809.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G3459

    Ginsenoside Rg2

    Triterpene saponin found in species of Panax.

    ≥98%
  • S6232

    Spiramycin

    Macrolide; protein synthesis inhibitor. ≥3900...

    ≥3900 IU/mg
  • A2052

    Aflatoxin M1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • P698583

    Prostaglandin E2

    principal metabolic product of COX-2

    ≥98%
  • G7346

    GSK-2636771

    p110β PI3K inhibitor.

    ≥98%
  • K5606

    Kobe 2602

    Ras inhibitor.

    ≥98%
  • F4681

    Flumazenil

    GABA-A antagonist.

    ≥98%
  • A5326

    Aniracetam

    AMPA positive allosteric modulator, D2, 5-HT2A,...

    ≥98%
  • C5260

    C-type Natriuretic Peptide (1-22), pig/human/rat

    Endogenous cardiomodulatory peptide; NPR-B agon...

    ≥95%
  • C000078

    C-178

    STING inhibitor

    ≥99%
  • A985132

    AZD-8186

    Selective inhibitor of PI3Kβ and PI3Kδ.

    ≥99%
  • C0246

    Calcimycin

    Polyether pyrrole, divalent cation ionophore.

    ≥98%
  • T3034

    Thienylethyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • E6376

    Eptifibatide

    Glycoprotein IIb/IIIa inhibitor.

    ≥98%
  • M3232

    Methylisoindigotin

    Indirubin derivative.

    ≥98%
  • A8070

    Auraptene

    Monoterpene coumarin ether found in Citrus; PPA...

    ≥98%
  • F3206

    Fibrinolysis Inhibiting Factor

    Peptide; fibrinolysis inhibitor.

    ≥98%
  • E2258

    Efonidipine Hydrochloride

    Calcium channel blocker.

    ≥98%
  • N1822

    Nefazodone Hydrochloride

    5-HT2 antagonist, SERT and NET inhibitor, hERG ...

    ≥98%
  • D1746

    Deltarasin Hydrochloride Trihydrate

    PDEδ inhibitor.

    ≥99%