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Oligomycin B

Oligomycin B

Product ID O4532
Cas No. 11050-94-5
Purity ≥97%, TLC, HPLC
Product Unit SizeCostQuantityStock
1 mg $116.10 In stock
5 mg $478.10 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Oligomycin B is a macrolide antibiotic initially produced by several species of Streptomyces. Oligomycin B inhibits mitochondrial F1F0 ATP synthase, binding the F0 subunit, inhibiting ATP synthesis; it displays antibacterial efficacy against a variety of bacteria. In myocardial tissue, oligomycin B decreases ATP concentrations and contractile function under normoxic conditions, but instead decreases the ATP depletion rate during ischemic or hypoxic conditions. When administered in large doses, oligomycin B causes hypertension, bradycardia, increased arterial PO2, and metabolic acidosis. Oligomycin B inhibits mitochondrial function and is often used to mimic hypoxia-induced conditions.

Product Info

Cas No.

11050-94-5

Purity

≥97%, TLC, HPLC

Formula

C45H72O12

Formula Wt.

805.05

IUPAC Name

(1R,4S,5E,5'R,6'R,7E,10S,11R,12S,14R,15S,16S,18R,19S,20R,21E,25S,26R, 27R,29S)-4-ethyl-11,12,15,19-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5', 10,12,14,16,18,20,26,29-nonamethylspiro[24, 28-dioxabicyclo[23.3.1]nonacosa-5,7,21-triene-27,2'-oxane]-3',13,17, 23-tetrone

Melting Point

156-164°C

Solubility

Soluble in DMSO, ethanol, acetone.

Appearance

White powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

O4532 MSDS PDF

Info Sheet

O4532 Info Sheet PDF

References

Grover GJ, Malm J. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26(4):287-96. PMID: 19035880.

Grover GJ, Atwal KS, Sleph PG, et al. Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1747-55. Erratum in: Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H484. PMID: 15371268.

Koos BJ, Sameshima H, Power GG. Fetal breathing movement, sleep state and cardiovascular responses to an inhibitor of mitochondrial ATPase in sheep. J Dev Physiol. 1986 Feb;8(1):67-75. PMID: 2937831.

Custom Order

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