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Orexin B, human

Orexin B, human

Product ID O7116
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $278.30 Please Inquire
1 mg $504.00 Please Inquire
2.5 mg $787.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Orexin B is an endogenous peptide neurotransmitter that activates orexin-2 receptors (OX2), controlling pituitary functions and increasing secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Orexin B is also involved in sleep, arousal, and feeding behaviors. This compound exhibits neuroprotective and orexigenic activities. Orexin B increases phosphorylation of Akt, increasing neuronal viability and protecting neurons against oxidative stress. Orexin B also decreases latency to eating, increases feeding behavior, decreases anxiety, and increases arousal in vivo. Orexin B stimulates insulin secretion in the pancreas of rats in a β-adrenergic receptor-dependent manner.

Product Info

Purity

≥95%

Formula

C123H212N44O35S

Formula Wt.

2899.4

Chemical Name

Hypocretin-2

Solubility

Soluble in water (1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

O7116 MSDS PDF

Info Sheet

O7116 Info Sheet PDF

References

Cataldi NI, Lux Lantos VA, Libertun C. Orexin A and B in vitro modify orexins receptors expression and gonadotropins secretion of anterior pituitary cells of proestrous rats. Regul Pept. 2014 Jan 10;188:25-30. PMID: 24333629.

Sokołowska P, Urbańska A, Biegańska K, et al. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J Mol Neurosci. 2014 Jan;52(1):48-55. PMID: 24243084.

Tsuji T, Yamamoto T, Tanaka S, et al. Analyses of the facilitatory effect of orexin on eating and masticatory muscle activity in rats. J Neurophysiol. 2011 Dec;106(6):3129-35. PMID: 21940607.

Adeghate E, Hameed R. Mechanism of orexin B-stimulated insulin and glucagon release from the pancreas of normal and diabetic rats. Pancreas. 2011 Jan;40(1):131-6. PMID: 20871474.

Di Sebastiano AR, Yong-Yow S, Wagner L, et al. Orexin mediates initiation of sexual behavior in sexually naive male rats, but is not critical for sexual performance. Horm Behav. 2010 Aug;58(3):397-404. PMID: 20541554.

Custom Order

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