Description
OSI-906 (Linsitinib) inhibits IGF-1R and InsR, displaying anticancer chemotherapeutic activity; it is currently in clinical trials as a potential treatment for colorectal cancer. In animal models of ovarian cancer, OSI-906 inhibits tumor development and growth. This compound also decreases tumor growth in animal models of fibroblast tumors. OSI-906 inhibits cell proliferation in colorectal cancer, breast cancer, pancreatic cancer, and non-small cell lung cancer (NSCLC) cells.