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Oxolinic Acid

Oxolinic Acid

Product ID O9458
Cas No. 14698-29-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $58.50 In stock
5 g $101.00 In stock
25 g $449.10 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
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Description

Oxolinic acid is a fluoroquinolone antibiotic that is used in plants and veterinary medicine; it’s antibacterial efficacy stems from inhibition of bacterial DNA gyrase. When combined with metals such as ruthenium, manganese, nickel, or zinc, the metal-oxolinic acid complex intercalates with DNA. Additionally, oxolinic acid may lower the threshold for induction of seizure through activation of excitatory amino acid receptors.

Product Info

Cas No.

14698-29-4

Purity

≥98%

Formula

C13H11NO5

Formula Wt.

261.23

Chemical Name

5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid

IUPAC Name

5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid

Synonym

Nidantin, Dioxacin, Emyrenil

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O9458 MSDS PDF

Info Sheet

O9458 Info Sheet PDF

References

Kljun J, Bratsos I, Alessio E, et al. New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium. Inorg Chem. 2013 Aug 5;52(15):9039-52. PMID: 23886077.

Tarushi A, Lafazanis K, Kljun J, et al. First- and second-generation quinolone antibacterial drugs interacting with zinc(II): structure and biological perspectives. J Inorg Biochem. 2013 Apr;121:53-65. PMID: 23353082.

Kwon HR, Choi GJ, Choi YH, et al. Suppression of pine wilt disease by an antibacterial agent, oxolinic acid. Pest Manag Sci. 2010 Jun;66(6):634-9. PMID: 20151406.

Williams PD, Helton DR. The proconvulsive activity of quinolone antibiotics in an animal model. Toxicol Lett. 1991 Sep;58(1):23-8. PMID: 1897004.

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