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Oxymetazoline is a sympathomimetic imidazoline derivative that exhibits vasoconstrictive and antioxidative activities; it acts as an agonist at α1-adrenergic receptors and a partial agonist at α2-adrenergic receptors. Oxymetazoline is clinically used as a decongestant. This compound also inhibits lipid peroxidation and acts as a radical scavenger in vitro.
| Cas No. | 2315-02-8 |
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| Purity | ≥98% |
| Formula | C16H24N2O • HCl |
| Formula Wt. | 296.84 |
| Chemical Name | 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenyl hydrochloride |
| IUPAC Name | 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2, 4-dimethylphenol;hydrochloride |
| Synonym | Afrin, Iliadin, Nafrine, Sinex, 2-(3-Hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline hydrochloride, 2-(4-tert-Butyl-2,6-dimethyl-3-hydro xybenzyl)-2-imidazoline hydrochloride |
| Melting Point | 300-303°C (dec) |
| Solubility | Soluble in water (145 mg/mL), and ethanol (270 mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Browning S, Housley D, Richards R, et al. The effects of oxymetazoline on lysozyme secretion from the human nasal mucosa. Acta Otolaryngol. 1997 Nov;117(6):851-5. PMID: 9442826.
Westerveld GJ, Scheeren RA, Dekker I, et al. Anti-oxidant actions of oxymethazoline and xylomethazoline. Eur J Pharmacol. 1995 Sep 15;291(1):27-31. PMID: 8549644.
Chen KS, Bharaj SS, King EC. Induction and relief of nasal congestion in ferrets infected with influenza virus. Int J Exp Pathol. 1995 Feb;76(1):55-64. PMID: 7537523.