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P7C3

P7C3

Product ID P0013
Cas No. 301353-96-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $67.80 In stock
5 mg $127.90 In stock
25 mg $480.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

P7C3 is an aminopropyl carbazole that displays neuroprotective, antidepressant, and cognition enhancing activities, particularly in models of Parkinson’s disease and amyotrophic lateral sclerosis (ALS). P7C3 promotes neurogenesis in vivo in the hippocampal dentate gyrus, preventing neuron apoptosis in newborn mice, and also prevents neuron death and cognitive decline in aged mice. P7C3 rescues TGF-β ligand mutation-induced retinal apoptosis in vivo. In C. elegans models, this compound inhibits MPP+-mediated death of dopaminergic neurons. Also, when given prior to expected symptom onset, P7C3 delays disease progression in animal models of ALS.

Product Info

Cas No.

301353-96-8

Purity

≥98%

Formula

C21H18Br2N2O

Formula Wt.

474.2

Chemical Name

1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol

IUPAC Name

1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol

Solubility

DMSO (30mg/ml)

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P0013 MSDS PDF

Info Sheet

P0013 Info Sheet PDF

References

Asai-Coakwell M, March L, Dai XH, et al. Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies. Hum Mol Genet. 2013 Apr 1;22(7):1432-42. PMID: 23307924.

De Jesús-Cortés H, Xu P, Drawbridge J, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. PMID: 23027934.

Tesla R, Wolf HP, Xu P, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. PMID: 23027932.

MacMillan KS, Naidoo J, Liang J, et al. Development of proneurogenic, neuroprotective small molecules. J Am Chem Soc. 2011 Feb 9;133(5):1428-37. PMID: 21210688

Pieper AA, Xie S, Capota E, et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51. PMID: 20603013.

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