Description
Paliperidone is an antipsychotic compound that inhibits D2 receptors and 5-HT2A receptors and is used to treat schizophrenia. Paliperidone also attenuates epinephrine- and serotonin-induced platelet aggregation.
Product Unit Size | Cost | Quantity | Stock |
---|
Paliperidone is an antipsychotic compound that inhibits D2 receptors and 5-HT2A receptors and is used to treat schizophrenia. Paliperidone also attenuates epinephrine- and serotonin-induced platelet aggregation.
Cas No. | 144598-75-4 |
---|---|
Purity | ≥97% |
Formula | C23H27FN4O3 |
Formula Wt. | 426.48 |
IUPAC Name | 3-[2-[4-(6-fluoro-1, 2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8, 9-tetrahydropyrido[1,2-a]pyrimidin-4-one |
Synonym | 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, 9-OH-risperidone |
Melting Point | 158-160°C |
Solubility | DMSO: >5 mg/mL |
Appearance | An offwhite or pale yellow powder |
Store Temp | Ambient |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Kozielska M, Johnson M, Pilla Reddy V, et al. Pharmacokinetic-pharmacodynamic modeling of the D2 and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats. Pharm Res. 2012 Jul;29(7):1932-48. PMID: 22437487.
Gilday E, Nasrallah HA. Clinical pharmacology of paliperidone palmitate a parenteral long-acting formulation for the treatment of schizophrenia. Rev Recent Clin Trials. 2012 Feb;7(1):2-9. PMID: 22023179.
De Clerck F, Somers Y, Mannaert E, et al. In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis. Clin Ther. 2004 Aug;26(8):1261-73. PMID: 15476907.
STING inhibitor
Steroid 5-α-reductase inhibitor.
Endogenous peptide hormone, involved in water h...
CDK4/6 inhibitor.
Pim kinase inhibitor.
Macrolide; threonyl-tRNA synthetase/ligase inhi...
Avermectin; glu-gated Cl- channel activator, Gl...
Peptide, inactive mastoparan analog used to mea...
Cyclohexanecarboxylic acid found in various pla...
Flavonoid found in Rhus verniciflua and Butea m...
Monoterpene found in various plant sources.
MEK1/2 and Raf inhibitor.
Inhibitor of T-lymphokine-activated killer cell...
AMPK activator, D1-4, 5-HT1A/2/3/6/7, M1-5 mACh...
Polyphenol found in Gossypium; calcineurin and ...
Endogenous hormone involved in circadian rhythm...
Abl inhibitor.
p110α inhibitor.
Stem cell neurogenesis inducer.
Bipyridamine toxin.