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Pancreatic polypeptide is an endogenous neuropeptide Y-family hormone that exhibits anorexigenic activity. Pancreatic polypeptide binds the Y4 receptor to decrease food intake, increase locomotor activity, and stimulate colonic muscle contractions and transit. Decreased secretion of pancreatic polypeptide is associated with improvements in pancreatic β-cell function in subjects with type 2 diabetes.
| Cas No. | 58591-52-9 |
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| Purity | ≥95% |
| Formula | C190H283N53O58 |
| Formula Wt. | 4237.69 |
| Synonym | Pancreatic hormone, avian, PPY |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Kahleova H, Mari A, Nofrate V, et al. Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes. J Diabetes Complications. 2012 Sep-Oct;26(5):442-9. PMID: 22673566.
Hankir MK, Parkinson JR, Minnion JS, et al. Peptide YY 3-36 and pancreatic polypeptide differentially regulate hypothalamic neuronal activity in mice in vivo as measured by manganese-enhanced magnetic resonance imaging. J Neuroendocrinol. 2011 Apr;23(4):371-80. PMID: 21251093.
Moriya R, Fujikawa T, Ito J, et al. Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice. Eur J Pharmacol. 2010 Feb 10;627(1-3):258-64. PMID: 19818748.
Liu YL, Semjonous NM, Murphy KG, et al. The effects of pancreatic polypeptide on locomotor activity and food intake in mice. Int J Obes (Lond). 2008 Nov;32(11):1712-5. PMID: 18779824.