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Pelitinib

Pelitinib

Product ID P1845
Cas No. 257933-82-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $127.90 In stock
10 mg $240.30 In stock
25 mg $518.40 In stock
100 mg $1,472.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pelitinib is an irreversible EFGR inhibitor that exhibits anticancer chemotherapeutic benefit in the treatment of non-small cell lung cancer (NSCLC) and other solid tumor cancers. In vitro, pelitinib inhibits NF-κB, inhibiting transcription of TERT and telomerase activity. Pelitinib also decreases phosphorylation of Akt and ERK and induces cell cycle arrest in vitro.

Product Info

Cas No.

257933-82-7

Purity

≥98%

Formula

C24H23ClFN5O2

Formula Wt.

467.92

Chemical Name

(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

IUPAC Name

(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4- (dimethylamino)but-2-enamide

Synonym

EKB-569

Melting Point

188-190°C (lit.)

Solubility

Insoluble in water. Soulble in DMSO (≥13 mg/mL).

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P1845 MSDS PDF

Info Sheet

P1845 Info Sheet PDF

References

Aravindan N, Aravindan S, Herman TS, et al. EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma. Radiat Res. 2013 Mar;179(3):304-12. PMID: 23379415.

Kim H, Lim HY. Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. J Korean Med Sci. 2011 Dec;26(12):1563-8. PMID: 22147992.

Yoshimura N, Kudoh S, Kimura T, et al. EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer. 2006 Mar;51(3):363-8. PMID: 16364494.

Custom Order

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