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PIK-75 Hydrochloride

PIK-75 Hydrochloride

Product ID P3540
Cas No. 372196-77-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $72.10 In stock
25 mg $288.40 In stock
100 mg $901.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PIK-75 is an inhibitor of p110α PI3K that exhibits anticancer and anti-inflammatory activities. In breast cancer cells, PIK-75 inhibits cell motility and adhesion in vitro and in vivo. PIK-75 also enhances glucose-induced insulin secretion. Additionally, PIK-75 inhibits production of TNF-α, IL-6, E-selectin, ICAM-1, and VCAM-1, preventing monocyte-endothelial cell adhesion.

Product Info

Cas No.

372196-77-5

Purity

≥98%

Formula

C16H14BrN5O4S • HCl

Formula Wt.

488.74

IUPAC Name

N-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide;hydrochloride

Synonym

PIK-75 HCl

Melting Point

221-223°C

Solubility

Soluble in DMSO(4mg/mL), DMF Water Insoluble Ethanol Insoluble

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P3540 MSDS PDF

Info Sheet

P3540 Info Sheet PDF

References

Buchanan CM, Dickson JM, Lee WJ, et al. Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity. PLoS One. 2013 Aug 1;8(8):e71337. PMID: 23936502.

Aoyagi K, Ohara-Imaizumi M, Nishiwaki C, et al. Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells. PLoS One. 2012;7(10):e47381. PMID: 23077605.

Smirnova T, Zhou ZN, Flinn RJ, et al. Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene. 2012 Feb 9;31(6):706-15. PMID: 21725367.

Dagia NM, Agarwal G, Kamath DV, et al. A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner. Am J Physiol Cell Physiol. 2010 Apr;298(4):C929-41. PMID: 20089935.

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