• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PIK-75 Hydrochloride

PIK-75 Hydrochloride

Product ID P3540
Cas No. 372196-77-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $72.10 In stock
25 mg $288.40 In stock
100 mg $901.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PIK-75 is an inhibitor of p110α PI3K that exhibits anticancer and anti-inflammatory activities. In breast cancer cells, PIK-75 inhibits cell motility and adhesion in vitro and in vivo. PIK-75 also enhances glucose-induced insulin secretion. Additionally, PIK-75 inhibits production of TNF-α, IL-6, E-selectin, ICAM-1, and VCAM-1, preventing monocyte-endothelial cell adhesion.

Product Info

Cas No.

372196-77-5

Purity

≥98%

Formula

C16H14BrN5O4S • HCl

Formula Wt.

488.74

IUPAC Name

N-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide;hydrochloride

Synonym

PIK-75 HCl

Melting Point

221-223°C

Solubility

Soluble in DMSO(4mg/mL), DMF Water Insoluble Ethanol Insoluble

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P3540 MSDS PDF

Info Sheet

P3540 Info Sheet PDF

References

Buchanan CM, Dickson JM, Lee WJ, et al. Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity. PLoS One. 2013 Aug 1;8(8):e71337. PMID: 23936502.

Aoyagi K, Ohara-Imaizumi M, Nishiwaki C, et al. Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells. PLoS One. 2012;7(10):e47381. PMID: 23077605.

Smirnova T, Zhou ZN, Flinn RJ, et al. Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene. 2012 Feb 9;31(6):706-15. PMID: 21725367.

Dagia NM, Agarwal G, Kamath DV, et al. A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner. Am J Physiol Cell Physiol. 2010 Apr;298(4):C929-41. PMID: 20089935.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C6019

    C-Peptide, human

    Endogenous peptide, connects A and B chains of ...

    ≥95%
  • S7603

    Stavudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥99%
  • A7657

    Atosiban Acetate

    Peptide, alters uterine contractility; V1/2 and...

    ≥95%
  • D5611

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19) Methyl Ester

    Essential fatty acid found in fish oil, involve...

    ≥99%
  • A1332

    Adipokinetic Hormone II from Locusta migratoria

    Neuropeptide found in Locusta migratoria.

    ≥98%
  • P8270

    Purvalanol A

    Purine derivative; CDK inhibitor.

    ≥98%
  • B1992

    Bexarotene

    RXR agonist.

    ≥98%
  • G3557

    Ginsenoside Rh1

    Triterpene saponin found in species of Panax.

    ≥77%
  • T1012

    13-TES-Baccatin III

    Synthesis impurity

    ≥98%
  • T3305

    Tibolone

    Synthetic steroid hormone used in HRT; SERM, PR...

    ≥98%
  • P200002

    PF-07321332

    Inhibitor of coronaviruses

    ≥99%
  • P6264

    PPQ-102

    Pyramido-pyrrolo-quinoxalinedione; CFTR blocker...

    ≥98%
  • E537334

    Enniatin B

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • A4944

    Amlexanox

    Azoxanthone derivative; S100A12 and S100A13 inh...

    ≥99%
  • R0154

    Ranolazine Dihydrochloride

    Nav1.7 and Nav1.8 N1+ channel blocker.

    ≥98%
  • C1649

    β-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • L5862

    Lopinavir

    HIV protease inhibitor, SERCA inhibitor.

    ≥98%
  • B6805

    Bradykinin (1-7)

    Natriuretic, vasodilatory peptide fragment; B1/...

    ≥95%
  • C0021

    Cafestol Acetate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • T1968

    Terpinen-4-ol

    Monoterpene found in various plant sources.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only