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Pimobendan

Pimobendan

Product ID P3456
Cas No. 74150-27-9
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $68.30 In stock
25 mg $89.30 In stock
100 mg $189.00 In stock
500 mg $367.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pimobendan is a cardiovascular drug commonly used to treat congestive heart failure, dilated cardiomyopathy, and chronic valvular heart disease in veterinary medicine. This compound exhibits vasodilatory and antithrombotic activities, decreasing peripheral resistance and inhibiting platelet aggregation. Pimobendan selectively inhibits cardiac phosphodiesterase III (PDE3), increasing myocardial cAMP and causing positive inotropic effects such as an increase in heart rate, left ventricle systolic pressure, and left ventricle filling pressure, and a decrease in peripheral resistance (mean arterial pressure).

Product Info

Cas No.

74150-27-9

Purity

≥99%

Formula

C19H18N4O2

Formula Wt.

334.37

Chemical Name

3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4, 5-dihydro-1H-pyridazin-6-one

IUPAC Name

3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4, 5-dihydro-1H-pyridazin-6-one

Synonym

Acardi, pimobendane

Solubility

DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 5 mg/mL

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P3456 MSDS PDF

Info Sheet

P3456 Info Sheet PDF

References

Shipley EA, Hogan DF, Fiakpui NN, et al. In vitro effect of pimobendan on platelet aggregation in dogs. Am J Vet Res. 2013 Mar;74(3):403-7. PMID: 23438115.

Boyle KL, Leech E. A review of the pharmacology and clinical uses of pimobendan. J Vet Emerg Crit Care (San Antonio). 2012 Aug;22(4):398-408. PMID: 22928748.

Verdouw PD, Hartog JM, Duncker DJ, et al. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol. 1986 Jul 15;126(1-2):21-30. PMID: 2875884.

Scholz H, Meyer W. Phosphodiesterase-inhibiting properties of newer inotropic agents. Circulation. 1986 Mar;73(3 Pt 2):III99-108. PMID: 2417748.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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