Pirarubicin

Name: Pirarubicin
SKU: P3568
Availability: InStock

Product ID P3568

Cas No. 72496-41-4

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Pirarubicin is an anthracycline derivative of adriamycin that is clinically co-administered with other anticancer chemotherapeutics in the treatment of a variety of cancers. Pirarubicin is a DNA intercalator that inhibits topoisomerase II and DNA polymerase, inhibiting synthesis of DNA in vitro and in vivo. Pirarubicin induces G2 phase cell cycle arrest, inhibiting tumor growth and increasing survival rates in animal models of colon cancer. Additionally, pirarubicin induces endothelium-dependent relaxation of aortic tissue, likely due to modulation of signaling by endothelium-derived relaxing factor (EDRF).

Product Info

Cas No.	72496-41-4
Purity	≥98%
Formula	C₃₂H₃₇NO₁₂
Formula Wt.	627.64
Chemical Name	(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-[(2S)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
IUPAC Name	(9S)-7-[(2R,4S,5S, 6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9, 11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5, 12-dione
Synonym	THP
Melting Point	188-192°C (dec.)
Appearance	Orange red crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P3568 MSDS PDF
Info Sheet	P3568 Info Sheet PDF

References

Hiyama E, Ueda Y, Onitake Y, et al. A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT). Pediatr Surg Int. 2013 Oct;29(10):1071-5. PMID: 24026876.

Kataoka K, Naomoto Y, Muro M, et al. Antitumor effect of pirarubicin (THP) against human colon cancer transplanted into nude mice and the mechanism of cell cycle progression. Gan To Kagaku Ryoho. 1992 Mar;19(3):367-71. PMID: 1543363.

Hirano S, Agata N, Hara Y, et al. Pirarubicin-induced endothelium-dependent relaxation in rat isolated aorta. J Pharm Pharmacol. 1991 Dec;43(12):848-54. PMID: 1687584.

Schott B, Robert J. Comparative cytotoxicity, DNA synthesis inhibition and drug incorporation of eight anthracyclines in a model of doxorubicin-sensitive and -resistant rat glioblastoma cells. Biochem Pharmacol. 1989 Jan 1;38(1):167-72. PMID: 2910297.

Tanaka M, Yoshida S, Kimura K. Mechanism of inhibition of DNA polymerases by 4'-epiadriamycin and 4'-O-tetrahydropyranyladriamycin. Gann. 1983 Dec;74(6):829-36. PMID: 6365674.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Pirarubicin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

L-(-)-Norepinephrine Bitartrate Monohydrate

Erythromycin

Levofloxacin Hemihydrate

Salmon Calcitonin Acetate

Bisacodyl

MDL 29951

Phalloidin

Dehydroepiandrosterone

Capsanthin

Remdesivir

KB-0742 dihydrochloride

Thioridazine Hydrochloride

Artemether

PF-06447475

Sotalol Hydrochloride

AZD-7762 Hydrochloride

AZD-4547

Diallyl Trisulfide

D-Luciferin Sodium

3-Phenylpropyl Isothiocyanate

Footer