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Pirfenidone

Pirfenidone

Product ID P3469
Cas No. 53179-13-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $101.20 In stock
50 mg $354.40 In stock
250 mg $844.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pirfenidone is an anti-fibrotic and anti-inflammatory compound that is used to treat pulmonary fibrosis. Pirfenidone decreases fibroblast production, suppresses expression of TNF-α and IL-1β, and inhibits TGF-β-induced stimulation of collagen production. In vivo, this compound prevents the development of pulmonary fibrosis.

Product Info

Cas No.

53179-13-8

Purity

≥98%

Formula

C12H11NO

Formula Wt.

185.22

IUPAC Name

5-Methyl-1-phenyl-2(1H)-pyridinone

Solubility

H2O: >10 mg/mL at 60 °C (warming for 30 minutes) DMSO: >20 mg/mL

Appearance

Pale yellow to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P3469 MSDS PDF

Info Sheet

P3469 Info Sheet PDF

References

Xiang XH, Jiang TP, Zhang S, et al. Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein 47 and collagen type I in rat hepatic stellate cells in vitro. Mol Med Rep. 2015 Mar 3. [Epub ahead of print]. PMID: 25738437.

Cottin V, Maher T. Long-term clinical and real-world experience with pirfenidone in the treatment of idiopathic pulmonary fibrosis. Eur Respir Rev. 2015 Mar;24(135):58-64. PMID: 25726556.

Iyer SN, Wild JS, Schiedt MJ, et al. Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters. J Lab Clin Med. 1995 Jun;125(6):779-85. PMID: 7539478.

Custom Order

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