LKT Labs

Biochemicals for Life Science Research

Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

Product ID P0006
Cas No. 124123-15-5
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $136.50 In stock
1 mg $283.50 In stock
2.5 mg $556.50 In stock
Bulk Quote

Quicklinks

Description

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous peptide that stimulates cAMP production in the anterior pituitary. PACAP and PACAP-related peptide (PRP) regulate immune function and display increases in expression when hosts are challenged with bacterial pathogens. PACAP and PRP also control expression of reproductive hormones such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Additionally, PACAP and PRP bind the PAC1 receptor and VPAC1/2 receptors. PACAP itself inhibits K+ amplitude of delayed rectifier K+ channels, exhibiting anti-apoptotic activity in cerebellar granule cells.

Product Info

Cas No.

124123-15-5
Purity

≥95%
Formula

C203H331N63O53S
Formula Wt.

4534.36
Synonym

PACAP (1-38)
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P0006 MSDS PDF
Info Sheet

P0006 Info Sheet PDF

References

Nam BH, Moon JY, Kim YO, et al. Structural and functional characterization of pituitary adenylyl cyclase-activating polypeptide (PACAP)/PACAP-related peptide (PRP) and its receptor in olive flounder (Paralichthys olivaceus). Comp Biochem Physiol B Biochem Mol Biol. 2013 Jan;164(1):18-28. PMID: 23026070.

Tam JK, Lee LT, Cheng CH, et al. Discovery of a new reproductive hormone in teleosts: pituitary adenylate cyclase-activating polypeptide-related peptide (PRP). Gen Comp Endocrinol. 2011 Sep 15;173(3):405-10. PMID: 21703272.

Vaudry D, Falluel-Morel A, Bourgault S, et al. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev. 2009 Sep;61(3):283-357. PMID: 19805477.

Mei YA, Vaudry D, Basille M, et al. PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP. Eur J Neurosci. 2004 Mar;19(6):1446-58. PMID: 15066141.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B1668

    Berteroin

    Thio sulforaphane analog, ITC.

    ≥97%
  • T503720

    TMS

    Selective inhibitor of cytochrome P450 1B1 (CYP...

    ≥99%
  • C2800

    Chalcone

    Enone.

    ≥97%
  • A4930

    7-Aminoactinomycin D

    Actinomycin derivative used to study apoptosis ...

    ≥98%
  • L0248

    Laminin Peptide YIGSR

    Laminin-derived peptapeptide.

    ≥98%
  • E7209

    Escitalopram Oxalate

    S-enantiomer of citalopram; SERT inhibitor.

    ≥99%
  • D3262

    Dipropyl Sulfide

    Organosulfide found in Allium; cholesterol synt...

    ≥99%
  • B9200

    BX-795

    PDK1 inhibitor.

    ≥98%
  • F4581

    5-Fluorocytosine

    Synthetic antifungal.

    ≥98%
  • T1016

    Propyl Analog of Paclitaxel

    Fermentation impurity

    ≥95%
  • S0269

    SAR245409

    Pyridopyrimidinone; PI3K and mTOR inhibitor.

    ≥96%
  • D1776

    Desmopressin

    Synthetic vasopressin derivative; V2R agonist.<...

    ≥95%
  • G7862

    GTPL-5846

    GPR84 agonist.

    ≥98%
  • T0116

    2″,3″-Dihydrocephalomannine

    Cephalomannine derivative found in Taxus; poten...

    ≥96%
  • P6800

    Pravastatin Lactone

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • A4534

    Aliskiren Hemifumarate

    Renin inhibitor.

    ≥98%
  • I7557

    1-Isothiocyanato-6-(methylsulfonyl)-hexane

    Synthetic ITC, erysolin analog.

    ≥98%
  • I0502

    Ibandronate Sodium Monohydrate

    Bisphosphonate.

    ≥98%
  • C1613

    Cediranib

    VEGFR inhibitor.

    ≥98%
  • S5869

    Sorafenib Tosylate

    c-Raf, RET, VEGFR1 inhibitor, potential HMT inh...

    ≥99%