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Potassium Canrenoate

Potassium Canrenoate

Product ID P5878
Cas No. 2181-04-6
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $62.30 In stock
1 g $162.30 In stock
5 g $421.80 In stock
25 g $937.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Potassium canrenoate is a mineralocorticoid/aldosterone antagonist that exhibits cardioprotective, nephroprotective, antihypertensive, and anti-fibrotic activities. In animal models of cardiac ischemia/reperfusion, potassium canrenoate increases phosphorylation of ERK1/2 and Akt, decreasing infarct size in an adenosine receptor-dependent manner. Potassium canrenoate also improves high salt diet-induced renal dysfunction, reversing the effects of hypofiltration. Additionally, potassium canrenoate displays negative inotropic activity at high doses, decreasing heart rate, blood pressure, and ventricular contraction; it also prolongs ventricular repolarization and the refractory period.

Product Info

Cas No.

2181-04-6

Purity

≥98%

Formula

C22H29KO4

Formula Wt.

396.56

Chemical Name

(17α)-17-Hydroxy-3-oxopregna-4,6-diene-21- carboxylic acid γ-lactonne free acid potassium salt

IUPAC Name

potassium;3-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2, 8,9,11,12,14,15, 16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate

Synonym

Canrenoic acid Potassium salt, Kanrenol, Soldactone, Venactone

Solubility

Very soluble in water and alcohol. Insoluble in chloroform and ether.

Appearance

Pale yellow to yellow-brown crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P5878 MSDS PDF

Info Sheet

P5878 Info Sheet PDF

References

Schmidt K, Tissier R, Ghaleh B, et al. Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion. Eur Heart J. 2010 Jul;31(13):1655-62. PMID: 20028693.

Rugale C, Cordaillat M, Mimran A, et al. Time-course reduction of renal function in rats on high sodium intake: acute reversal by potassium canrenoate. Clin Exp Pharmacol Physiol. 2008 Apr;35(4):412-5. PMID: 18307731.

Sugiyama A, Satoh Y, Takahara A, et al. Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model. J Pharmacol Sci. 2004 Dec;96(4):436-43. PMID: 15599107.

Bos R, Mougenot N, Médiani O, et al. Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat. J Pharmacol Exp Ther. 2004 Jun;309(3):1160-6. PMID: 14764658.

Custom Order

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