• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PP-1

PP-1

Product ID P6232
Cas No. 172889-26-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 Please Inquire
5 mg $150.40 Please Inquire
25 mg $447.60 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PP-1 inhibits members of the Src kinase family and displays antioxidative, anti-inflammatory, and anti-arrhythmic characteristics. In an in vitro model of oxidative stress, PP-1 inhibits hydrogen peroxide-induced production of macrophage migration inhibitory factor (MIF). PP-1 decreases total and phosphorylated levels of Src and increases connexin-43 levels and gap junction communication. Additionally, PP-1 decreases ventricular tachycardia and sudden death in animal models of arrhythmia.

Product Info

Cas No.

172889-26-8

Purity

≥98%

Formula

C16H19N5

Formula Wt.

281.36

Chemical Name

4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine

IUPAC Name

1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine

Solubility

DMSO (25mg/ml), slightly soluble in ethanol

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P6232 MSDS PDF

Info Sheet

P6232 Info Sheet PDF

References

Rao F, Deng CY, Zhang QH, et al. Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells. Braz J Med Biol Res. 2013 Sep;46(9):746-51. PMID: 24036910.

Sovari AA, Iravanian S, Dolmatova E, et al. Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. PMID: 22093512.

Wijetunge S, Hughes AD. Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus. J Hypertens. 2007 Sep;25(9):1871-8. PMID: 17762651.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G3459

    Ginsenoside Rg2

    Triterpene saponin found in species of Panax.

    ≥98%
  • A985136

    AZD5991

    Mcl-1 inhibitor

    ≥99%
  • P0010

    Pituitary Adenylate Cyclase-activating Polypeptide-related Peptide, human

    Peptide, involved in paracrine and autocrine ce...

    ≥95%
  • M5610

    Moclobemide

    MAO-A inhibitor.

    ≥98%
  • G0278

    Gatifloxacin Sesquihydrate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • D5992

    Doxapram Hydrochloride Hydrate

    K+ channel blocker, catecholamine release stimu...

    ≥98%
  • P3198

    Phytanic Acid

    Fatty acid metabolite of chlorophyll; RXR and P...

    ≥97%
  • H8162

    (−)-Huperzine A

    Sesquiterpene alkaloid found in Huperzia serrat...

    ≥97%
  • I4000

    Ikarugamycin

    Protein translation inhibitor.

    ≥98%
  • F8272

    Fusarenon X

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%
  • E622698

    Eprosartan Mesylate

    Nonpeptide angiotensin II receptor antagonist

    ≥99%
  • G4480

    Glucagon, human

    Endogenous peptide hormone, counteracts insulin...

    ≥95%
  • S2792

    SGX-523

    MET inhibitor.

    ≥98%
  • P9768

    Pyronaridine Tetraphosphate

    Hemantin inhibitor.

    ≥98%
  • C451338

    Clioquinol

    Antifungal agent with neuroprotective activity....

    ≥98%
  • I4659

    Iloperidone

    Benzisoxazole phenylethanone; D2 and 5-HT2A ant...

    ≥99%
  • C4800

    CM346 Hydrochloride

    Potential anxiolytic.

    ≥99%
  • M3368

    Mirtazapine

    Piperazine; 5-HT1 agonist, 5-HT2/3 and α2-adre...

    ≥98%
  • I088240

    (S,S)-ICG-001

    Wnt/β-catenin inhibitor

    ≥98%
  • G2969

    Growth Hormone Releasing Hexapeptide

    Synthetic peptide hormone, met-enkephalin analo...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only