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Prion Peptide (106-126), human

Prion Peptide (106-126), human

Product ID P7034
Cas No. 148439-49-0
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $196.20 In stock
2 mg $343.60 In stock
5 mg $498.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Prion peptide (106-126) (PrP106-126) is a synthetic glycoprotein that mimics a segment of cellular prion protein expressed in neurons and other cells. Prp106-126 forms amyloid-like fibrils and upregulates expression of IL-1β, TNF-α, and matrix metalloproteinases 1, 3, and 11 (MMP1/3/11) in astrocytes and microglia. In other cellular models, PrP106-126 increases levels of ROS and activates ERK1/2, p38, and JNK1/2, amplifying normal PrP signaling and causing oxidative stress and neuronal injury. PrP106-126 also binds the p75 neurotrophin receptor (the low-affinity NGF receptor; p75NTR) and, separately, alters microglial phagocytic activity.

Product Info

Cas No.

148439-49-0

Purity

≥95%

Formula

C80H128N26O34S2

Formula Wt.

1912.28

Solubility

Soluble in water (1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P7034 MSDS PDF

Info Sheet

P7034 Info Sheet PDF

References

Song K, Na JY, Oh MH, et al. Synthetic prion Peptide 106-126 resulted in an increase matrix metalloproteinases and inflammatory cytokines from rat astrocytes and microglial cells. Toxicol Res. 2012 Mar;28(1):5-9. PMID: 24278583.

Pietri M, Caprini A, Mouillet-Richard S, et al. Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J Biol Chem. 2006 Sep 22;281(38):28470-9. PMID: 16864581.

Ciesielski-Treska J, Grant NJ, Ulrich G, et al. Fibrillar prion peptide (106-126) and scrapie prion protein hamper phagocytosis in microglia. Glia. 2004 Apr 15;46(2):101-15. PMID: 15042579.

Della-Bianca V, Rossi F, Armato U, et al. Neurotrophin p75 receptor is involved in neuronal damage by prion peptide-(106-126). J Biol Chem. 2001 Oct 19;276(42):38929-33. PMID: 11489911.

Custom Order

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