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Propofol

Propofol

Product ID P6870
Cas No. 2078-54-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $45.40 In stock
25 g $86.80 In stock
100 g $142.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Propofol is an agonist at GABA-A receptors and antagonist at voltage-gated Na+ channels and NMDA receptors; it also modulates Ca2+ signaling. Propofol displays anesthetic, sedative/hypnotic, neuroprotective, and nephroprotective activities. Propofol is a short-acting intravenous anesthetic that depresses the central nervous system, decreases cerebral blood flow, and decreases intracranial pressure. In a middle cerebral artery occlusion (MCAO) model of cerebral ischemia/reperfusion, propofol decreases expression of aquaporins 1 and 4 (AQ-1 and AQ-4), matrix metalloproteinases 2 and 9 (MMP2/9), and HIF-1α, decreasing edema and disruption of the blood-brain barrier. Propofol also increases expression of μ-opioid receptors in neuroblastoma cells. Additionally, this compound normalizes osmolality, serum creatine, and levels of AQP-2, ICAM-1, TNF-α, Bcl-2, and Bax in kidneys, improving renal function in animal models of endotoxemia-induced kidney injury.

Product Info

Cas No.

2078-54-8

Purity

≥98%

Formula

C12H18O

Formula Wt.

178.27

IUPAC Name

2,6-di(propan-2-yl)phenol

Synonym

2,6-Bis(isopropyl)phenol, 2,6-Diisopropylphenol

Solubility

100mM in DMSO and ethanol

Appearance

Yellow to red liquid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P6870 MSDS PDF

Info Sheet

P6870 Info Sheet PDF

References

Lee JH, Cui HS, Shin SK, et al. Effect of propofol post-treatment on blood-brain barrier integrity and cerebral edema after transient cerebral ischemia in rats. Neurochem Res. 2013 Nov;38(11):2276-86. PMID: 23990224.

Li Z, Pei Q, Cao L, et al. Propofol increases µ-opioid receptor expression in SH-SY5Y human neuroblastoma cells. Mol Med Rep. 2012 Dec;6(6):1333-6. PMID: 22965315.

Cui WY, Tian AY, Bai T. Protective effects of propofol on endotoxemia-induced acute kidney injury in rats. Clin Exp Pharmacol Physiol. 2011 Nov;38(11):747-54. PMID: 21824173.

Kotani Y, Shimazawa M, Yoshimura S, et al. The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties. CNS Neurosci Ther. 2008 Summer;14(2):95-106. PMID: 18482023.

Salmi E, Kaisti KK, Metsähonkala L, et al. Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans. Anesth Analg. 2004 Nov;99(5):1420-6. PMID: 15502041.

Yamanoue T, Brum JM, Estafanous FG. Vasodilation and mechanism of action of propofol in porcine coronary artery. Anesthesiology. 1994 Aug;81(2):443-51. PMID: 8053594.

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