• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Purmorphamine

Purmorphamine

Product ID P8370
Cas No. 483367-10-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $87.20 In stock
5 mg $165.50 In stock
25 mg $650.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Purmorphamine is an agonist at Smoothened (Smo) receptors; it stimulates activity in the Hedgehog signaling pathway. Purmorphamine displays neuroprotective, pro-angiogenic, and anti-osteoporotic activities. In mesenchymal stem cells, this compound decreases proliferation, increases alkaline phosphatase activity, and accelerates osteogenesis. In animal models of stroke, purmorphamine restores neurological deficits, decreases neuronal apoptosis, and increases neovascularization. Purmorphamine also inhibits the induction of autophagy in hepatocellular carcinoma cells.

Product Info

Cas No.

483367-10-8

Purity

≥98%

Formula

C31H32N6O2

Formula Wt.

520.64

IUPAC Name

9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthyloxy)-9H-purin-6-amine

Solubility

100mM in DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P8370 MSDS PDF

Info Sheet

P8370 Info Sheet PDF

References

Wöltje M, Böbel M, Heiland M, et al. Purmorphamine and oxysterols accelerate and promote osteogenic differentiation of mesenchymal stem cells in vitro. In Vivo. 2015 Mar-Apr;29(2):247-54. PMID: 25792653.

Chechneva OV, Mayrhofer F, Daugherty DJ, et al. A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell Death Dis. 2014 Oct 23;5:e1481. PMID: 25341035.

Wang Y, Han C, Lu L, et al. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology. 2013 Sep;58(3):995-1010. PMID: 23504944.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M5756

    Montelukast Sodium

    CysLT1 antagonist.

    ≥98%
  • C0173

    Carmustine

    Nitrosourea, DNA alkylator.

    ≥98%
  • U7354

    Usnic Acid

    Dibenzofuran produced by lichens.

    ≥98%
  • C2800

    Chalcone

    Enone.

    ≥97%
  • C4532

    Clindamycin Hydrochloride

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • V3253

    Vinblastine Sulfate

    Vinca alkaloid found in Catharanthus; microtubu...

    ≥96%
  • A9803

    Azathioprine

    Purine nucleotide analog, mercaptiopurine prodr...

    ≥98%
  • P2858

    4-α-Phorbol-12-myristate-13-acetate

    Negative control for PKC activation.

    ≥98%
  • M2408

    MGCD-265 Analog

    MET inhibitor.

    ≥98%
  • I0010

    5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

    Intermediate in the synthesis of purine analogs...

    ≥98%
  • D023721

    Dasatinib

    Multikinase inhibitor.

    ≥99%
  • E544766

    Enterocin

    A bacteriocin

    ≥95%
  • B6801

    Brassinin

    Phytoalexin, indole found in cruciferous vegeta...

    ≥98%
  • A5056

    Amorolfine Hydrochloride

    14α-demethylase inhibitor.

    ≥98.5%
  • N1982

    Neuromedin U, rat

    Endogenous neuropeptide, involved in energy hom...

    ≥95%
  • B8377

    5-tert-Butoxyquinazoline-2,4-diamine

    Diaminoquinazoline derivative.

    ≥98%
  • R0243

    Raloxifene Hydrochloride

    SERM.

    ≥98%
  • C2970

    Chrysophanol

    Anthraquinone found in Rheum.

    ≥98%
  • N7604

    Naltriben

    δ2OR antagonist.

    ≥95%
  • P0256

    Pantoprazole Sodium Sesquihydrate

    H+/K+ ATPase and ROCK-2 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only