• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PX-866

PX-866

Product ID P9200
Cas No. 502632-66-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $76.10 In stock
5 mg $245.10 In stock
10 mg $421.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PX-866 is a wortmannin analog that inhibits PI3K, exhibiting anticancer chemotherapeutic and anti-angiogenic activities. PX-866 is currently in clinical trials as a standalone or combination therapy in the treatment of advanced solid tumors. PX-866 inhibits invasion and angiogenesis and induces autophagy in glioblastoma cells. In animal models of cancer, PX-866 inhibits tumor growth and increases survival time. PX-866 also inhibits motility of cancer cells.

Product Info

Cas No.

502632-66-8

Purity

≥98%

Formula

C29H35NO8

Formula Wt.

525.59

Chemical Name

(1E,​4S,​4aR,​5R,​6aS,​9aR)-​5-​(acetyloxy)-​1-​[(di-​2-​propen-​1-​ylamino)methylene]-​4,​4a,​5,​6,​6a,​8,​9,​9a-​octahydro-​11-​hydroxy-​4-​(methoxymethyl)-​4a,​6a-​dimethyl-​cyclopenta[5,​6]naphtho[1,​2-​c]pyran-​2,​7,​10(1H)-​trione

IUPAC Name

[(3aR,6E,9S,9aR,10R,11aS)-6-[[bis(prop-2-enyl)amino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-1,4,7-trioxo-2,3,3a,9,10,11-hexahydroindeno[4,5-h]isochromen-10-yl] acetate

Synonym

Sonolisib

Melting Point

102°C-107°C

Solubility

Methanol , DMSO(50mM), Ethyl acetate, Ethanol

Appearance

Orange Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P9200 MSDS PDF

Info Sheet

P9200 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Bowles DW, Ma WW, Senzer N, et al. A multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours. Br J Cancer. 2013 Sep 3;109(5):1085-92. PMID: 23942080.

Koul D, Shen R, Kim YW, et al. Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. Neuro Oncol. 2010 Jun;12(6):559-69. PMID: 20156803.

Howes AL, Chiang GG, Lang ES, et al. The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol Cancer Ther. 2007 Sep;6(9):2505-14. PMID: 17766839.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L1785

    Levofloxacin Hemihydrate

    Fluoroquinolone, S-(-) isomer of ofloxacin; top...

    ≥98%
  • I7155

    Isoindigo

    Potential AhR binding agent.

    ≥98%
  • G5752

    Gonadorelin Acetate

    Synthetic peptide, GnRH derivative; GnRH agonist.
    ≥95%
  • N1980

    Neuromedin B, pig

    Endogenous bombesin-related peptide, involved i...

    ≥95%
  • C6132

    CPI-203

    Triazolothienodiazepine, JQ-1 derivative; BRD i...

    ≥98%
  • T162051

    Tebipenem

    Broad-spectrum antibiotic

    ≥99%
  • L8262

    Lupinine

    Alkaloid found in species of Loranthus, Calia, ...

    ≥98%
  • A1333

    Adipokinetic Hormone II from Schistocera gregaria

    Neuropeptide found in Schistocera gregaria.

    ≥95%
  • E5575

    Entacapone

    COMT inhibitor.

    ≥98%
  • P8168

    Puromycin Dihydrochloride

    Protein synthesis inhibitor, DPP2 and metallope...

    ≥98%
  • T3039

    Thienyloctyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • R0154

    Ranolazine Dihydrochloride

    Nav1.7 and Nav1.8 N1+ channel blocker.

    ≥98%
  • D5610

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19)

    Essential fatty acid found in fish oil, involve...

    ≥98%
  • E5241

    Met-Enkephalin

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%
  • P200637

    PF-04745637

    TRPA1 antagonist

    ≥98%
  • N5778

    Notoginsenoside R1

    Triterpene saponin found in species of Panax.

    ≥98%
  • S6800

    SR1001

    RORα/γ inverse agonist.

    ≥99%
  • C9879

    Cytochalasin B

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • B011460

    Baloxavir Marboxil

    Cap-dependent endonuclease inhibitor

    ≥ 99%
  • N1744

    Nelarabine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only